RMM 46

Discontinued Product

RMM 46 (Cat. No. 5909) has been withdrawn from sale for commercial reasons.
Description: MSK/RSK family kinase inhibitor
Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Purity: ≥98% (HPLC)

Biological Activity for RMM 46

RMM 46 is a MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Technical Data for RMM 46

M. Wt 450.5
Formula C24H26N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1307896-46-3
PubChem ID 67206797
Smiles [H]/C(C1=CC=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C2=C1)=C(C#N)\C(NC(C)(C)CO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RMM 46

References are publications that support the biological activity of the product.

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID: 23540679

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Keywords: RMM 46, RMM 46 supplier, RMM46, RSK2, 3, MSK1, inhibitors, inhibits, family, kinases, CREB, phosphorylation, RSK, 5909, Tocris Bioscience

Citations for RMM 46

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Currently there are no citations for RMM 46.

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