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RMM 46

Cat. No. 5909 Submit a Review Datasheet / COA / SDS
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Cat.No. 5909 - RMM 46 | C24H26N4O5 | CAS No. 1307896-46-3
Description: MSK/RSK family kinase inhibitor
Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Technical Data

M. Wt 450.5
Formula C24H26N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1307896-46-3
PubChem ID 67206797
InChI Key FCCMYBKAZCDQGX-LZYBPNLTSA-N
Smiles [H]/C(C1=CC=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C2=C1)=C(C#N)\C(NC(C)(C)CO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 450.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID: 23540679

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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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  • MAPK Signaling
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