RMM 46

Pricing Availability   Qty
Cat.No. 5909 - RMM 46 | C24H26N4O5 | CAS No. 1307896-46-3
Description: MSK/RSK family kinase inhibitor
Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for RMM 46

RMM 46 is a MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Technical Data for RMM 46

M. Wt 450.5
Formula C24H26N4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1307896-46-3
PubChem ID 67206797
Smiles [H]/C(C1=CC=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C2=C1)=C(C#N)\C(NC(C)(C)CO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RMM 46

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.05 100

Preparing Stock Solutions for RMM 46

The following data is based on the product molecular weight 450.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.2 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for RMM 46

References are publications that support the biological activity of the product.

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID: 23540679

If you know of a relevant reference for RMM 46, please let us know.

View Related Products by Target

View Related Products by Product Action

View all RSK Inhibitors

Keywords: RMM 46, RMM 46 supplier, RMM46, RSK2, 3, MSK1, inhibitors, inhibits, family, kinases, CREB, phosphorylation, RSK, 5909, Tocris Bioscience

Citations for RMM 46

Citations are publications that use Tocris products.

Currently there are no citations for RMM 46. Do you know of a great paper that uses RMM 46 from Tocris? Please let us know.

Reviews for RMM 46

There are currently no reviews for this product. Be the first to review RMM 46 and earn rewards!

Have you used RMM 46?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases