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Submit ReviewRMM 46
Discontinued Product
RMM 46 (Cat. No. 5909) has been withdrawn from sale for commercial reasons.
Description: MSK/RSK family kinase inhibitor
Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
Purity: ≥98% (HPLC)
Biological Activity for RMM 46
RMM 46 is a MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
Technical Data for RMM 46
| M. Wt | 450.5 |
| Formula | C24H26N4O5 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1307896-46-3 |
| PubChem ID | 67206797 |
| InChI Key | FCCMYBKAZCDQGX-LZYBPNLTSA-N |
| Smiles | [H]/C(C1=CC=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C2=C1)=C(C#N)\C(NC(C)(C)CO)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RMM 46
References for RMM 46
References are publications that support the biological activity of the product.
Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID: 23540679
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Keywords: RMM 46, RMM 46 supplier, RMM46, RSK2, 3, MSK1, inhibitors, inhibits, family, kinases, CREB, phosphorylation, RSK, 5909, Tocris Bioscience
Citations for RMM 46
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Currently there are no citations for RMM 46.
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Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases