RIPK2 inhibitor 1

Pricing Availability   Qty
Description: Potent RIPK2 inhibitor
Chemical Name: 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide
Purity: ≥98% (HPLC)

Biological Activity for RIPK2 inhibitor 1

RIPK2 inhibitor 1 is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 of 5-10 nM). It inhibits NF-κB activity and decreases cancer cell proliferation by 70%. In vivo, RIPK2 inhibitor 1 inhibits intestinal and lung inflammation with low toxicity in rodent models.

Technical Data for RIPK2 inhibitor 1

M. Wt 410.48
Formula C25H22N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1290490-78-6
PubChem ID 99506096
Smiles CN1C=CN=C1C2=CC(NC(C3=CC(NC(C4=CC=CC=C4)=O)=C(C)C=C3)=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RIPK2 inhibitor 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.05 100

Preparing Stock Solutions for RIPK2 inhibitor 1

The following data is based on the product molecular weight 410.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for RIPK2 inhibitor 1

References for RIPK2 inhibitor 1

References are publications that support the biological activity of the product.

Salla et al (2018) Identification and characterization of novel receptor-interacting serine/threonine-protein kinase 2 inhibitors using structural similarity analysis. J.Pharmacol.Exp.Ther. 365 354 PMID: 29555876

If you know of a relevant reference for RIPK2 inhibitor 1, please let us know.

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Citations for RIPK2 inhibitor 1

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