Remoxipride hydrochloride

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Cat.No. 0916 - Remoxipride hydrochloride | C16H23BrN2O3.HCl | CAS No. 73220-03-8
Description: Selective D2-like antagonist
Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for Remoxipride hydrochloride

Remoxipride hydrochloride is a dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data for Remoxipride hydrochloride

M. Wt 407.73
Formula C16H23BrN2O3.HCl
Storage Store at RT
CAS Number 73220-03-8
PubChem ID 15565709
InChI Key WCPXLMIPGMFZMY-MERQFXBCSA-N
Smiles BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Remoxipride hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for Remoxipride hydrochloride

The following data is based on the product molecular weight 407.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.26 mL 24.53 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for Remoxipride hydrochloride

Certificate of Analysis / Product Datasheet
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References for Remoxipride hydrochloride

References are publications that support the biological activity of the product.

Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356 PMID: 9400011

Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to DA D2 and D3 receptors. Eur.J.Pharmacol. 238 121 PMID: 8405075

Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1 PMID: 1978466

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991


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1 Citation for Remoxipride hydrochloride

Citations are publications that use Tocris products. Selected citations for Remoxipride hydrochloride include:

André et al (2011) Differential electrophysiological changes in striatal output neurons in Huntington's disease. J Neurosci 31 1170 PMID: 21273402


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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