Remoxipride hydrochloride

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Cat.No. 0916 - Remoxipride hydrochloride | C16H23BrN2O3.HCl | CAS No. 73220-03-8
Description: Selective D2-like antagonist
Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
Datasheet
Citations
Literature

Biological Activity

Dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.

Technical Data

M. Wt 407.73
Formula C16H23BrN2O3.HCl
Storage Store at RT
CAS Number 73220-03-8
PubChem ID 15565709
InChI Key WCPXLMIPGMFZMY-MERQFXBCSA-N
Smiles BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 407.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.26 mL 24.53 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356 PMID: 9400011

Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors. Eur.J.Pharmacol. 238 121 PMID: 8405075

Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1 PMID: 1978466

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991


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Keywords: selective D2-like antagonists dopamine non-selective receptor antagonist dopaminergic d2 Non-selective Dopamine

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