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Submit ReviewRemoxipride hydrochloride
Description: Selective D2-like antagonist
Chemical Name: (S)-(-)-3-Bromo-N-[(1-ethyl-2-pyrrolidinylmethyl]2,6-dimethoxybenzamide hydrochloride
Biological Activity for Remoxipride hydrochloride
Remoxipride hydrochloride is a dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.
Technical Data for Remoxipride hydrochloride
| M. Wt | 407.73 |
| Formula | C16H23BrN2O3.HCl |
| Storage | Store at RT |
| CAS Number | 73220-03-8 |
| PubChem ID | 15565709 |
| InChI Key | WCPXLMIPGMFZMY-MERQFXBCSA-N |
| Smiles | BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Remoxipride hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Remoxipride hydrochloride
The following data is based on the product molecular weight 407.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.26 mL | 24.53 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for Remoxipride hydrochloride
References for Remoxipride hydrochloride
References are publications that support the biological activity of the product.
Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356 PMID: 9400011
Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to DA D2 and D3 receptors. Eur.J.Pharmacol. 238 121 PMID: 8405075
Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1 PMID: 1978466
Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
If you know of a relevant reference for Remoxipride hydrochloride, please let us know.
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Keywords: Remoxipride hydrochloride, Remoxipride hydrochloride supplier, selective, D2-like, antagonists, dopamine, non-selective, receptor, antagonist, dopaminergic, d2, Non-selective, Dopamine, 0916, Tocris Bioscience
1 Citation for Remoxipride hydrochloride
Citations are publications that use Tocris products. Selected citations for Remoxipride hydrochloride include:
André et al (2011) Differential electrophysiological changes in striatal output neurons in Huntington's disease. J Neurosci 31 1170 PMID: 21273402
Do you know of a great paper that uses Remoxipride hydrochloride from Tocris? Please let us know.
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