Remoxipride hydrochloride
Biological Activity
Dopamine D2 receptor antagonist showing selectivity over D3 and D4 receptors (Ki values are ~ 300, ~ 1600, and ~ 2800 nM for D2, D3 and D4 receptors respectively). Exhibits antipsychotic activity in vivo with no extrapyramidal side effects. 50-fold more potent than sulpiride in antagonising the effects of apomorphine in the rat.
Technical Data
| M. Wt | 407.73 |
| Formula | C16H23BrN2O3.HCl |
| Storage | Store at RT |
| CAS Number | 73220-03-8 |
| PubChem ID | 15565709 |
| InChI Key | WCPXLMIPGMFZMY-MERQFXBCSA-N |
| Smiles | BrC1=CC=C(OC)C(C(NC[C@@]2(CCCN2CC)[H])=O)=C1OC.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 407.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.26 mL | 24.53 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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References
References are publications that support the products' biological activity.
Ahlenius et al (1997) In vivo effects of remoxipride and aromatic ring metabolites in the rat. J.Pharmacol.Exp.Ther. 283 1356 PMID: 9400011
Mohell et al (1993) Binding characteristics of remoxipride and its metabolites to dopamine D2 and D3 receptors. Eur.J.Pharmacol. 238 121 PMID: 8405075
Sedvall (1990) Development of a new antipsychotic remoxipride. Acta Psychiatr.Scand.Suppl. 358 1 PMID: 1978466
Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991
If you know of a relevant reference for Remoxipride hydrochloride, please let us know.
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Keywords: selective D2-like antagonists dopamine non-selective receptor antagonist dopaminergic d2 Non-selective Dopamine
Citations for Remoxipride hydrochloride
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