Potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.7 mL||28.5 mL||57 mL|
|2.5 mM||1.14 mL||5.7 mL||11.4 mL|
|5 mM||0.57 mL||2.85 mL||5.7 mL|
|25 mM||0.11 mL||0.57 mL||1.14 mL|
References are publications that support the biological activity of the product.
Daly et al (1981) Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br.J.Pharmacol. 72 49 PMID: 6112034
Daly et al (1981) Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. Br.J.Pharmacol. 72 55 PMID: 6112035
Brittain and Daly (1981) A review of the animal pharmacology of ranitidine - a new, selective histamine H2-antagonist. Scand.J.Gastroenterol.Suppl. 69 1
If you know of a relevant reference for Ranitidine hydrochloride, please let us know.
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Keywords: Ranitidine hydrochloride, Ranitidine hydrochloride supplier, Selective, H2, antagonists, receptors, histamine, histaminergic, h2, antagonist, Histamine, Receptors, 1967, Tocris Bioscience
1 Citation for Ranitidine hydrochloride
Citations are publications that use Tocris products. Selected citations for Ranitidine hydrochloride include:
Kwiatkowski et al (2013) Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia. J Exp Biol 216 1827 PMID: 23393282
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Literature in this Area
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