Ranitidine hydrochloride

Discontinued Product

Ranitidine hydrochloride (Cat. No. 1967) has been withdrawn from sale for commercial reasons.
Description: Selective H2 antagonist
Chemical Name: N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethanediamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Ranitidine hydrochloride

Ranitidine hydrochloride is a potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions.

Technical Data for Ranitidine hydrochloride

M. Wt 350.86
Formula C13H22N4O3S.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 66357-59-3
PubChem ID 657344
Smiles Cl[H].CN\C(NCCSCC1=CC=C(CN(C)C)O1)=C\N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ranitidine hydrochloride

References for Ranitidine hydrochloride

References are publications that support the biological activity of the product.

Daly et al (1981) Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br.J.Pharmacol. 72 49 PMID: 6112034

Daly et al (1981) Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. Br.J.Pharmacol. 72 55 PMID: 6112035

Brittain and Daly (1981) A review of the animal pharmacology of ranitidine - a new, selective histamine H2-antagonist. Scand.J.Gastroenterol.Suppl. 69 1

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Keywords: Ranitidine hydrochloride, Ranitidine hydrochloride supplier, Selective, H2, antagonists, receptors, histamine, histaminergic, h2, antagonist, Histamine, Receptors, 1967, Tocris Bioscience

1 Citation for Ranitidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Ranitidine hydrochloride include:

Kwiatkowski et al (2013) Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia. J Exp Biol 216 1827 PMID: 23393282

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.