Ranitidine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1967 - Ranitidine hydrochloride | C13H22N4O3S.HCl | CAS No. 66357-59-3
Description: Selective H2 antagonist
Chemical Name: N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethanediamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Potent, selective and competitive histamine H2 receptor antagonist (pA2 = 6.95 - 7.2). Inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food in vivo. Also inhibits aspirin-induced gastric lesions.

Technical Data

M. Wt 350.86
Formula C13H22N4O3S.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 66357-59-3
PubChem ID 657344
Smiles Cl[H].CN\C(NCCSCC1=CC=C(CN(C)C)O1)=C\N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.77 25mM with gentle warming
ethanol 8.77 25
water 17.54 50

Preparing Stock Solutions

The following data is based on the product molecular weight 350.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.25 mL 28.5 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Daly et al (1981) Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br.J.Pharmacol. 72 49 PMID: 6112034

Daly et al (1981) Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. Br.J.Pharmacol. 72 55 PMID: 6112035

Brittain and Daly (1981) A review of the animal pharmacology of ranitidine - a new, selective histamine H2-antagonist. Scand.J.Gastroenterol.Suppl. 69 1 PMID:

If you know of a relevant reference for Ranitidine hydrochloride, please let us know.

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Keywords: Ranitidine hydrochloride, supplier, Selective, H2, antagonists, receptors, histamine, histaminergic, h2, antagonist, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience

1 Citation for Ranitidine hydrochloride

Citations are publications that use Tocris products. Selected citations for Ranitidine hydrochloride include:

Kwiatkowski et al (2013) Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia. J Exp Biol 216 1827 PMID: 23393282

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