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Biological Activity for Radicicol
Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.
Technical Data for Radicicol
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Radicicol
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Radicicol
The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.97 mL||54.83 mL||109.66 mL|
|1.25 mM||2.19 mL||10.97 mL||21.93 mL|
|2.5 mM||1.1 mL||5.48 mL||10.97 mL|
|12.5 mM||0.22 mL||1.1 mL||2.19 mL|
References for Radicicol
References are publications that support the biological activity of the product.
Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47 PMID: 11911945
Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221 PMID: 7694864
Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435 PMID: 10478836
If you know of a relevant reference for Radicicol, please let us know.
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Keywords: Radicicol, Radicicol supplier, Hsp90, inhibitors, inhibits, Antifungal, antibiotics, Heat, Shock, Proteins, 90, Antibiotics, Antifungals, 1589, Tocris Bioscience
2 Citations for Radicicol
Citations are publications that use Tocris products. Selected citations for Radicicol include:
Ginzberg et al (2018) Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity. Elife 7 PMID: 29889021
Stecklein et al (2012) BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci U S A 109 13650 PMID: 22869732
Do you know of a great paper that uses Radicicol from Tocris? Please let us know.
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
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- DNA Damage Repair
- Targeted Protein Degradation
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- Chemotherapy Targets
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