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Description: Hsp90 inhibitor. Antifungal antibiotic
Chemical Name: (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Radicicol

Radicicol is an antifungal antibiotic. Inhibits heat shock protein 90 (Hsp90) activity by binding to the ATP-binding pocket, subsequently suppressing cell transformation induced by src, ras and mos. Represses estrogen receptor transcriptional activity and inhibits angiogenesis.

Technical Data for Radicicol

M. Wt 364.78
Formula C18H17ClO6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 12772-57-5
PubChem ID 6323491
Smiles O=C2/C=C/C=C\[C@@H](O3)[C@H]3C[C@@H](C)OC(C1=C(O)C=C(O)C(Cl)=C1C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Radicicol

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 3.65 10

Preparing Stock Solutions for Radicicol

The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.41 mL 137.07 mL 274.14 mL
0.5 mM 5.48 mL 27.41 mL 54.83 mL
1 mM 2.74 mL 13.71 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL

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Product Datasheets for Radicicol

Certificate of Analysis / Product Datasheet
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References for Radicicol

References are publications that support the biological activity of the product.

Lee et al (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. Mol.Cell.Endocrinol. 188 47 PMID: 11911945

Oikawa et al (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis. Eur.J.Pharmacol. 241 221 PMID: 7694864

Schulte et al (1999) Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. Mol.Endocrinol. 13 1435 PMID: 10478836

If you know of a relevant reference for Radicicol, please let us know.

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Keywords: Radicicol, Radicicol supplier, Hsp90, inhibitors, inhibits, Antifungal, antibiotics, Heat, Shock, Proteins, 90, Antibiotics, Antifungals, 1589, Tocris Bioscience

2 Citations for Radicicol

Citations are publications that use Tocris products. Selected citations for Radicicol include:

Ginzberg et al (2018) Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity. Elife 7 PMID: 29889021

Stecklein et al (2012) BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci U S A 109 13650 PMID: 22869732

Do you know of a great paper that uses Radicicol from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
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