R18

Pricing Availability   Qty
Cat.No. 2144 - R18 | Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro | CAS No. 211364-78-2
Description: Inhibitor of 14.3.3 proteins
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity for R18

R18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

Technical Data for R18

M. Wt 2309.69
Formula C101H157N27O29S3
Sequence PHCVPRDLSWLDLEANMCLP
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 211364-78-2
PubChem ID 16138697
InChI Key YSKZRNFKZLWXRG-ZHTKBQOPSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for R18

Solubility Soluble to 1 mg/ml in water

Product Datasheets for R18

Certificate of Analysis / Product Datasheet
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References for R18

References are publications that support the biological activity of the product.

Wang et al (1999) Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 38 12499 PMID: 10493820

Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193 PMID: 11577088

Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360


If you know of a relevant reference for R18, please let us know.

View Related Products by Product Action

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Keywords: R18, R18 supplier, inhibitors, inhibits, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3, Proteins, 2144, Tocris Bioscience

Citations for R18

Citations are publications that use Tocris products.

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Reviews for R18

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for R18

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.