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Glutamate dehydrogenase (GHD1) inhibitor (IC50 = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 264.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.57 mL||37.84 mL||75.68 mL|
|2.5 mM||1.51 mL||7.57 mL||15.14 mL|
|5 mM||0.76 mL||3.78 mL||7.57 mL|
|25 mM||0.15 mL||0.76 mL||1.51 mL|
References are publications that support the biological activity of the product.
Jin et al (2015) Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 27 257 PMID: 25670081
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Keywords: R162, R162 supplier, glutamate, dehydrogenase, inhibitor, inhibits, GDH1, Other, Dehydrogenases, 6054, Tocris Bioscience
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