R162

Pricing Availability   Qty
Cat.No. 6054 - R162 | C17H12O3 | CAS No. 64302-87-0
Description: Glutamate dehydrogenase (GDH1) inhibitor
Chemical Name: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Glutamate dehydrogenase (GHD1) inhibitor (IC50 = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.

Technical Data

M. Wt 264.28
Formula C17H12O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 64302-87-0
PubChem ID 4412951
InChI Key IMUBGIOLZQTIGI-UHFFFAOYSA-N
Smiles OC1=C2C(C3=CC=CC=C3C(C2=CC=C1CC=C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 264.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.57 mL 37.84 mL 75.68 mL
2.5 mM 1.51 mL 7.57 mL 15.14 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
25 mM 0.15 mL 0.76 mL 1.51 mL

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References

References are publications that support the biological activity of the product.

Jin et al (2015) Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 27 257 PMID: 25670081


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Keywords: R162, R162 supplier, glutamate, dehydrogenase, inhibitor, inhibits, GDH1, Other, Dehydrogenases, 6054, Tocris Bioscience

Citations for R162

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Literature in this Area

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