Pricing Availability   Qty
Cat.No. 6054 - R162 | C17H12O3 | CAS No. 64302-87-0
Description: Glutamate dehydrogenase (GDH1) inhibitor
Chemical Name: 1-Hydroxy-2-(2-propen-1-yl)-9,10-anthracenedione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Glutamate dehydrogenase (GHD1) inhibitor (IC50 = 23 μM). Decreases fumarate and ROS levels, attenuates glutathione peroxidase levels and inhibits cell proliferation in cancer cell lines. Attenuates viability of a range of cancer cell lines.

Technical Data

M. Wt 264.28
Formula C17H12O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 64302-87-0
PubChem ID 4412951
Smiles OC1=C2C(C3=CC=CC=C3C(C2=CC=C1CC=C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 264.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.57 mL 37.84 mL 75.68 mL
2.5 mM 1.51 mL 7.57 mL 15.14 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
25 mM 0.15 mL 0.76 mL 1.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.


References are publications that support the biological activity of the product.

Jin et al (2015) Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 27 257 PMID: 25670081

If you know of a relevant reference for R162, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Inhibitors

Keywords: R162, R162 supplier, glutamate, dehydrogenase, inhibitor, inhibits, GDH1, Other, Dehydrogenases, 6054, Tocris Bioscience

Citations for R162

Citations are publications that use Tocris products.

Currently there are no citations for R162. Do you know of a great paper that uses R162 from Tocris? Please let us know.

Reviews for R162

There are currently no reviews for this product. Be the first to review R162 and earn rewards!

Have you used R162?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells