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Biological Activity for Quipazine dimaleate
Quipazine dimaleate is a selective 5-HT3 receptor agonist. Also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.
Technical Data for Quipazine dimaleate
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Quipazine dimaleate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Quipazine dimaleate
The following data is based on the product molecular weight 445.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.25 mL||11.23 mL||22.45 mL|
|5 mM||0.45 mL||2.25 mL||4.49 mL|
|10 mM||0.22 mL||1.12 mL||2.25 mL|
|50 mM||0.04 mL||0.22 mL||0.45 mL|
Product Datasheets for Quipazine dimaleate
References for Quipazine dimaleate
References are publications that support the biological activity of the product.
Ireland and Tyers (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 90 229 PMID: 3814920
Peroutka and Hamik (1988) [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes. Eur.J.Pharmacol. 148 297 PMID: 3378579
Sharif et al (1991) Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br.J.Pharmacol. 102 919 PMID: 1830236
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Keywords: Quipazine dimaleate, Quipazine dimaleate supplier, 5-HT3, agonists, Serotonin, Receptors, 0629, Tocris Bioscience
1 Citation for Quipazine dimaleate
Citations are publications that use Tocris products. Selected citations for Quipazine dimaleate include:
Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin. Br J Pharmacol 37 321 PMID: 21956448
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.