Quipazine dimaleate

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Cat.No. 0629 - Quipazine dimaleate | C13H15N3.2C4H4O4 | CAS No. 150323-78-7
Description: 5-HT3 agonist
Chemical Name: 2-(1-Piperazinyl)quinoline dimaleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective 5-HT3 receptor agonist. Also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.

Technical Data

M. Wt 445.43
Formula C13H15N3.2C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 150323-78-7
PubChem ID 6420043
InChI Key VAOSOCRJSSWBEQ-SPIKMXEPSA-N
Smiles OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.23 mL 22.45 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ireland and Tyers (1987) Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 90 229 PMID: 3814920

Peroutka and Hamik (1988) [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes. Eur.J.Pharmacol. 148 297 PMID: 3378579

Sharif et al (1991) Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding. Br.J.Pharmacol. 102 919 PMID: 1830236


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Keywords: Quipazine dimaleate, supplier, 5-HT3, agonists, Serotonin, Receptors, 5-HT3, Receptors, Tocris Bioscience

1 Citation for Quipazine dimaleate

Citations are publications that use Tocris products. Selected citations for Quipazine dimaleate include:

Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Br J Pharmacol 37 321 PMID: 21956448


Do you know of a great paper that uses Quipazine dimaleate from Tocris? If so please let us know.

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Reviews

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Quipazine dimaleate

Protocols

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