Quinolinic acid

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Cat.No. 0225 - Quinolinic acid | C7H5NO4 | CAS No. 89-00-9
Description: Endogenous NMDA agonist and transmitter candidate
Chemical Name: Pyridine-2,3-dicarboxylic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Technical Data

M. Wt 167.12
Formula C7H5NO4
Storage Store at RT
CAS Number 89-00-9
PubChem ID 1066
InChI Key GJAWHXHKYYXBSV-UHFFFAOYSA-N
Smiles OC(=O)C1=C(N=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 8.36 50

Preparing Stock Solutions

The following data is based on the product molecular weight 167.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.97 mL 59.84 mL 119.67 mL
2.5 mM 2.39 mL 11.97 mL 23.93 mL
5 mM 1.2 mL 5.98 mL 11.97 mL
25 mM 0.24 mL 1.2 mL 2.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Monaghan and Beaton (1991) Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur.J.Pharmacol. 194 123 PMID: 1676371

Prada de Carvalho et al (1996) The endogenous agonist quinolinic acid and the non-endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem.Int. 28 445 PMID: 8740453

Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 30 333 PMID: 2830636

Stone and Perkins (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in the rat CNS. Eur.J.Pharmacol. 72 411 PMID: 6268428


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Keywords: Quinolinic acid, Quinolinic acid supplier, agonists, Transmitter, candidate, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0225, Tocris Bioscience

1 Citation for Quinolinic acid

Citations are publications that use Tocris products. Selected citations for Quinolinic acid include:

Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Nat Commun 18 PMID: 25522418


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