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Submit ReviewQuinolinic acid
Description: Endogenous NMDA agonist and transmitter candidate
Chemical Name: Pyridine-2,3-dicarboxylic acid
Biological Activity
Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.
Technical Data
| M. Wt | 167.12 |
| Formula | C7H5NO4 |
| Storage | Store at RT |
| CAS Number | 89-00-9 |
| PubChem ID | 1066 |
| InChI Key | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=C(N=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 8.36 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 167.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 11.97 mL | 59.84 mL | 119.67 mL |
| 2.5 mM | 2.39 mL | 11.97 mL | 23.93 mL |
| 5 mM | 1.2 mL | 5.98 mL | 11.97 mL |
| 25 mM | 0.24 mL | 1.2 mL | 2.39 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Monaghan and Beaton (1991) Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur.J.Pharmacol. 194 123 PMID: 1676371
Prada de Carvalho et al (1996) The endogenous agonist quinolinic acid and the non-endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem.Int. 28 445 PMID: 8740453
Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 30 333 PMID: 2830636
Stone and Perkins (1981) Quinolinic acid: a potent endogenous excitant at amino acid receptors in the rat CNS. Eur.J.Pharmacol. 72 411 PMID: 6268428
If you know of a relevant reference for Quinolinic acid, please let us know.
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Keywords: Quinolinic acid, Quinolinic acid supplier, agonists, Transmitter, candidate, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0225, Tocris Bioscience
1 Citation for Quinolinic acid
Citations are publications that use Tocris products. Selected citations for Quinolinic acid include:
Tsutsui-Kimura et al (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Nat Commun 18 PMID: 25522418
Do you know of a great paper that uses Quinolinic acid from Tocris? Please let us know.
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