Quinelorane hydrochloride

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Cat.No. 1519 - Quinelorane hydrochloride | C14H22N4.2HCl | CAS No. 97548-97-5
Description: D2 and D3 agonist
Alternative Names: LY 163502
Chemical Name: (5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-amine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Dopamine D2 and D3 receptor agonist; Ki values are 5.7 and 3.4 nM respectively.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M. Wt 319.27
Formula C14H22N4.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 97548-97-5
PubChem ID 68728
InChI Key WDEMLQIGYYLRRX-OWVUFADGSA-N
Smiles [H][C@]23[C@@](CCCN3CCC)([H])CC1=NC(N)=NC=C1C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.98 25

Preparing Stock Solutions

The following data is based on the product molecular weight 319.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 12.53 mL 62.64 mL 125.29 mL
1.25 mM 2.51 mL 12.53 mL 25.06 mL
2.5 mM 1.25 mL 6.26 mL 12.53 mL
12.5 mM 0.25 mL 1.25 mL 2.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Foreman et al (1989) Preclinical studies on quinelorane, a potent and highly selective D2-DArgic agonist. J.Pharmacol.Exp.Ther. 250 227 PMID: 2526214

Eaton et al (1994) Effects of the selective DArgic D2 agonist quinelorane on the activity of DArgic and noradrenergic neurons projecting to the diencephalon of the rat. J.Pharmacol.Exp.Ther. 268 645 PMID: 7906734

Flietstra and Levant (1998) Comparison of D2 and D3 DA receptor affinity of DArgic compounds in the rat brain. Life Sci. 62 1825 PMID: 9600324


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Keywords: Quinelorane hydrochloride, Quinelorane hydrochloride supplier, D2, D3, agonists, Dopamine, D2-like, Non-Selective, Receptors, dopaminergic, LY163502, LY, 163502, Non-selective, 1519, Tocris Bioscience

1 Citation for Quinelorane hydrochloride

Citations are publications that use Tocris products. Selected citations for Quinelorane hydrochloride include:

Baca et al (2013) Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice. Brain Res 1532 85 PMID: 23939223


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Reviews for Quinelorane hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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