Qc 1

Pricing Availability   Qty
Cat.No. 5055 - Qc 1 | C23H16F3N3O2S | CAS No. 403718-45-6
Description: Threonine dehydrogenase inhibitor
Chemical Name: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Reversible, non-competitive inhibitor of threonine dehydrogenase (TDH) (IC50 ~500 nM). Induces autophagy and inhibits cell proliferation in mouse embryonic stem (ES) cells.

Technical Data

M. Wt 455.45
Formula C23H16F3N3O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 403718-45-6
PubChem ID 5000754
Smiles O=C(N2C3=CC(C(F)(F)F)=CC=C3)C1=CC=C(C(NCC4=CC=CC=C4)=O)C=C1NC2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.77 50

Preparing Stock Solutions

The following data is based on the product molecular weight 455.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.39 mL 21.96 mL 43.91 mL
2.5 mM 0.88 mL 4.39 mL 8.78 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

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References are publications that support the biological activity of the product.

Alexander et al (2011) Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc.Natl.Acad.Sci.USA 108 15828 PMID: 21896756

If you know of a relevant reference for Qc 1, please let us know.

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Keywords: Qc 1, Qc 1 supplier, Qc1, threonine, dehydrogenase, inhibitors, inhibits, TDH, Other, Dehydrogenases, 5055, Tocris Bioscience

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Literature in this Area

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