Purvalanol A

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Description: Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 60
Chemical Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity: ≥98% (HPLC)
Citations (8)

Biological Activity for Purvalanol A

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries for Purvalanol A

Purvalanol A is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Purvalanol A

M. Wt 388.9
Formula C19H25ClN6O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 212844-53-6
PubChem ID 456214
Smiles ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Purvalanol A

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 19.45 50
DMSO 38.89 100

Preparing Stock Solutions for Purvalanol A

The following data is based on the product molecular weight 388.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.86 mL 25.71 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets for Purvalanol A

Certificate of Analysis / Product Datasheet
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References for Purvalanol A

References are publications that support the biological activity of the product.

Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533 PMID: 9677190

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859 PMID: 10495356

Villerbu et al (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 97 761 PMID: 11857351

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for Purvalanol A, please let us know.

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Keywords: Purvalanol A, Purvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, PurvalanolA, NG60, NG, 60, Kinase, Non-selective, CDKs, 1580, Tocris Bioscience

8 Citations for Purvalanol A

Citations are publications that use Tocris products. Selected citations for Purvalanol A include:

Ozlü et al (2010) Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics 9 336 PMID: 19786723

Rowe et al (2010) Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. Antiviral Res 86 276 PMID: 20307580

Pennati et al (2005) Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther 4 1328 PMID: 16170024

Karayel et al (2018) Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep 8 2269 PMID: 29396449

Do you know of a great paper that uses Purvalanol A from Tocris? Please let us know.

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