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Submit ReviewPotent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.
M. Wt | 3835.47 |
Formula | C155H249N51O47S8 |
Sequence |
GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK (Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30) (Modifications: Lys-35 = C-terminal amide) |
Storage | Store at -20°C |
CAS Number | 1396322-38-5 |
PubChem ID | 91691118 |
InChI Key | LQDOOZLFRLRWPQ-MKAGXXMWSA-N |
Smiles | [H]NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868 PMID: 22842000
Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680 PMID: 20437566
Keywords: Purotoxin 1, Purotoxin 1 supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, venoms, Receptors, 4922, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.