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Purotoxin 1

Cat. No. 4922 Submit a Review Datasheet / COA / SDS

Discontinued Product

Purotoxin 1 (Cat. No. 4922) has been withdrawn from sale for commercial reasons.
Description: Potent P2X3 modulator
Datasheet
Citations
Reviews
Literature (5)
Biological Activity Technical Data Datasheets References

Biological Activity for Purotoxin 1

Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.

Technical Data for Purotoxin 1

M. Wt 3835.47
Formula C155H249N51O47S8
Sequence GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK

(Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30)

(Modifications: Lys-35 = C-terminal amide)
Storage Store at -20°C
CAS Number 1396322-38-5
PubChem ID 91691118
InChI Key LQDOOZLFRLRWPQ-MKAGXXMWSA-N
Smiles [H]NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Purotoxin 1

References are publications that support the biological activity of the product.

Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868 PMID: 22842000

Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680 PMID: 20437566

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Keywords: Purotoxin 1, Purotoxin 1 supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, venoms, Receptors, 4922, Tocris Bioscience

Citations for Purotoxin 1

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