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Submit ReviewPurotoxin 1
Description: Potent P2X3 modulator
Biological Activity for Purotoxin 1
Potent P2X3 receptor modulator (IC50 = 12 nM). Exhibits negligible effects on P2X2 and P2X2/3. Demonstrates antinociceptive properties in an animal model of inflammatory pain.
Technical Data for Purotoxin 1
| M. Wt | 3835.47 |
| Formula | C155H249N51O47S8 |
| Sequence |
GYCAEKGIRCDDIHCCTGLKCKCNASGYNCVCRKK (Modifications: Disulfide bridge: 3-16,10-21,15-32, 23-30) (Modifications: Lys-35 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 1396322-38-5 |
| PubChem ID | 91691118 |
| InChI Key | LQDOOZLFRLRWPQ-MKAGXXMWSA-N |
| Smiles | [H]NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Purotoxin 1
References for Purotoxin 1
References are publications that support the biological activity of the product.
Kabanova et al (2012) Modulation of P2X3 receptors by spider toxins. Biochim.Biophys.Acta. 1818 2868 PMID: 22842000
Grishin et al (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. Ann.Neurol. 67 680 PMID: 20437566
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Keywords: Purotoxin 1, Purotoxin 1 supplier, P2X3, P2X, purinergics, receptors, modulators, antinociceptive, pain, inflammatory, venoms, Receptors, 4922, Tocris Bioscience
Citations for Purotoxin 1
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Currently there are no citations for Purotoxin 1.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.