(Z)-Pugnac

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Cat.No. 3384 - Pugnac | C15H19N3O7 | CAS No. 132489-69-1
Description: O-GlcNAcase and β-hexosaminidase inhibitor
Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.

Technical Data

M. Wt 353.33
Formula C15H19N3O7
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 132489-69-1
PubChem ID 6074876
InChI Key PBLNJFVQMUMOJY-JXAWBTAJSA-N
Smiles OC(C1NC(C)=O)C(O)C(CO)O/C1=N\OC(NC2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dong and Hart (1994) Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. J.Biol.Chem. 269 19321 PMID: 8034696

Macauley et al (2005) O-GlcNAcase uses substrate-assisted catalysis. J.Biol.Chem. 280 25313 PMID: 15795231

Perreira et al (2006) Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg.Med.Chem. 14 837 PMID: 16214344


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Keywords: O-GlcNAcase β-hexosaminidase beta-hexosaminidase O-GlcNAc-β-N-acetylglucosaminidase O-GlcNAc-beta-N-acetylglucosaminidase inhibitors inhibits Hydrolases Other Hydrolases

Citations for (Z)-Pugnac

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Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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