PU H71
Biological Activity
Potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
Technical Data
| M. Wt | 512.37 |
| Formula | C18H21IN6O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 873436-91-0 |
| PubChem ID | 9549213 |
| InChI Key | SUPVGFZUWFMATN-UHFFFAOYSA-N |
| Smiles | IC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 51.24 | 100 | |
| DMSO | 51.24 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 512.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.76 mL | 19.52 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
Molarity Calculator
Reconstitution Calculator
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
He et al (2006) Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J.Med.Chem. 49 381 PMID: 16392823
Chan et al (2008) Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 68 216 PMID: 18172314
Caldas-Lopes et al (2009) Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc.Natl.Acad.Sci.USA 106 8368 PMID: 19416831
If you know of a relevant reference for PU H71, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PUH71 heat shock proteins hsp90 inhibitors inhibits potent Hsp90
Citations for PU H71
Citations are publications that use Tocris products.
Currently there are no citations for PU H71. Do you know of a great paper that uses PU H71 from Tocris? If so please let us know.
Literature in this Area
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Parkinson's Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
