PU H71

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Cat.No. 3104 - PU H71 | C18H21IN6O2S | CAS No. 873436-91-0
Description: Potent Hsp90 inhibitor
Chemical Name: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

Technical Data

M. Wt 512.37
Formula C18H21IN6O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 873436-91-0
PubChem ID 9549213
InChI Key SUPVGFZUWFMATN-UHFFFAOYSA-N
Smiles IC1=CC4=C(OCO4)C=C1SC3=NC2=C(N)N=CN=C2N3CCCNC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 51.24 100
DMSO 51.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 512.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.52 mL
5 mM 0.39 mL 1.95 mL 3.9 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

He et al (2006) Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J.Med.Chem. 49 381 PMID: 16392823

Chan et al (2008) Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 68 216 PMID: 18172314

Caldas-Lopes et al (2009) Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc.Natl.Acad.Sci.USA 106 8368 PMID: 19416831


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Keywords: PUH71 heat shock proteins hsp90 inhibitors inhibits potent Hsp90

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Literature in this Area

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