PU 02

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Cat.No. 4700 - PU 02 | C16H12N4S | CAS No. 313984-77-9
Description: Negative allosteric modulator of 5-HT3
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Purity: ≥97% (HPLC)

Biological Activity

Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).

Technical Data

M. Wt 292.36
Formula C16H12N4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 313984-77-9
PubChem ID 720937
Smiles C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 292.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534

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Citations for PU 02

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for PU 02


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