PU 02

Pricing Availability Delivery Time Qty
Cat.No. 4700 - PU 02 | C16H12N4S | CAS No. 313984-77-9
Description: Negative allosteric modulator of 5-HT3
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).

Technical Data

M. Wt 292.36
Formula C16H12N4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 313984-77-9
PubChem ID 720937
InChI Key BGMSTNYJYPSLHN-UHFFFAOYSA-N
Smiles C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 292.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534


If you know of a relevant reference for PU 02, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Modulators

Keywords: PU 02, supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience

Citations for PU 02

Citations are publications that use Tocris products.

Currently there are no citations for PU 02. Do you know of a great paper that uses PU 02 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for PU 02

Protocols

TODO: Add Protocols