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Submit ReviewPU 02
Description: Negative allosteric modulator of 5-HT3 receptors
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Purity: ≥97% (HPLC)
Biological Activity for PU 02
PU 02 is a negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).
Technical Data for PU 02
| M. Wt | 292.36 |
| Formula | C16H12N4S |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 313984-77-9 |
| PubChem ID | 720937 |
| InChI Key | BGMSTNYJYPSLHN-UHFFFAOYSA-N |
| Smiles | C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PU 02
References for PU 02
References are publications that support the biological activity of the product.
Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534
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Keywords: PU 02, PU 02 supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Receptors, 4700, Tocris Bioscience
Citations for PU 02
Citations are publications that use Tocris products.
Currently there are no citations for PU 02.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.