PU 02

Pricing Availability   Qty
Cat.No. 4700 - PU 02 | C16H12N4S | CAS No. 313984-77-9
Description: Negative allosteric modulator of 5-HT3 receptors
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).

Technical Data

M. Wt 292.36
Formula C16H12N4S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 313984-77-9
PubChem ID 720937
InChI Key BGMSTNYJYPSLHN-UHFFFAOYSA-N
Smiles C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 292.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534


If you know of a relevant reference for PU 02, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Modulators

Keywords: PU 02, PU 02 supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, Receptors, 4700, Tocris Bioscience

Citations for PU 02

Citations are publications that use Tocris products.

Currently there are no citations for PU 02. Do you know of a great paper that uses PU 02 from Tocris? Please let us know.

Reviews for PU 02

There are currently no reviews for this product. Be the first to review PU 02 and earn rewards!

Have you used PU 02?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.