PSB 36

Pricing Availability Delivery Time Qty
Cat.No. 2019 - PSB 36 | C21H30N4O3 | CAS No. 524944-72-7
Description: Potent and selective A1 antagonist
Chemical Name: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Potent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).

Compound Libraries

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Technical Data

M. Wt 386.49
Formula C21H30N4O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 524944-72-7
PubChem ID 11689583
InChI Key CIBIXJYFYPFMTN-UHFFFAOYSA-N
Smiles CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.65 100
ethanol 38.65 100

Preparing Stock Solutions

The following data is based on the product molecular weight 386.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.87 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788

Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891 PMID:


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Keywords: PSB 36, supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, A1, Receptors, Tocris Bioscience

3 Citations for PSB 36

Citations are publications that use Tocris products. Selected citations for PSB 36 include:

Ziemlinska et al (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One 9 e88833 PMID: 24551172

Arnal et al (2013) Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. Respir Physiol Neurobiol 186 73 PMID: 23318703

Guerreiro et al (2008) Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol 74 980 PMID: 18621927


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Pathways for PSB 36

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