PSB 36

Discontinued Product

PSB 36 (Cat. No. 2019) has been withdrawn from sale for commercial reasons.
Cat.No. 2019 - PSB 36 | C21H30N4O3 | CAS No. 524944-72-7
Description: Potent and selective A1 antagonist
Chemical Name: 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (4)

Biological Activity for PSB 36

PSB 36 is a potent and selective A1 adenosine receptor antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. PSB 36 demonstrates greater selectivity than DPCPX (Cat. No. 0439). PSB 36 reduces atrial fibrillation in rat isolated beating heart preparations.

Technical Data for PSB 36

M. Wt 386.49
Formula C21H30N4O3
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 524944-72-7
PubChem ID 11689583
InChI Key CIBIXJYFYPFMTN-UHFFFAOYSA-N
Smiles CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PSB 36

References are publications that support the biological activity of the product.

Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788

Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

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Keywords: PSB 36, PSB 36 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, 2019, Tocris Bioscience

6 Citations for PSB 36

Citations are publications that use Tocris products. Selected citations for PSB 36 include:

Carlström et al (2010) Adenosine A(2) receptors modulate tubuloglomerular feedback. Am J Physiol Renal Physiol 299 F412 PMID: 20519378

Soattin et al (2020) Inhibition of adenosine pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 11 493 PMID: 32595514

Arnal et al (2013) Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. Respir Physiol Neurobiol 186 73 PMID: 23318703

Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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