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PSB 11 hydrochloride
Biological Activity for PSB 11 hydrochloride
PSB 11 hydrochloride is a potent and selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 36 nM).
Technical Data for PSB 11 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 11 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.91||20 with gentle warming|
Preparing Stock Solutions for PSB 11 hydrochloride
The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.07 mL||75.35 mL||150.69 mL|
|1 mM||3.01 mL||15.07 mL||30.14 mL|
|2 mM||1.51 mL||7.53 mL||15.07 mL|
|10 mM||0.3 mL||1.51 mL||3.01 mL|
Product Datasheets for PSB 11 hydrochloride
References for PSB 11 hydrochloride
References are publications that support the biological activity of the product.
Muller et al (2002) Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists. J.Med.Chem. 45 3440 PMID: 12139454
Muller (2003) Medicinal chemistry of adenosine A3 receptor ligands. Curr.Top.Med.Chem. 3 445 PMID: 12570761
Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A3 adenosine receptors. Bioorg.Med.Chem. 11 347 PMID: 12517430
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Citations for PSB 11 hydrochloride
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Literature in this Area
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