You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PSB 11 hydrochloride
Potent and selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 36 nM).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.91||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||15.07 mL||75.35 mL||150.69 mL|
|1 mM||3.01 mL||15.07 mL||30.14 mL|
|2 mM||1.51 mL||7.53 mL||15.07 mL|
|10 mM||0.3 mL||1.51 mL||3.01 mL|
References are publications that support the biological activity of the product.
Muller et al (2002) Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists. J.Med.Chem. 45 3440 PMID: 12139454
Muller (2003) Medicinal chemistry of adenosine A3 receptor ligands. Curr.Top.Med.Chem. 3 445 PMID: 12570761
Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A3 adenosine receptors. Bioorg.Med.Chem. 11 347 PMID: 12517430
If you know of a relevant reference for PSB 11 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: PSB 11 hydrochloride, PSB 11 hydrochloride supplier, Potent, selective, human, A3, receptor, antagonists, inverse, agonists, Receptors, adenosines, PSB11, hydrochloride, Adenosine, 2012, Tocris Bioscience
Citations for PSB 11 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for PSB 11 hydrochloride. Do you know of a great paper that uses PSB 11 hydrochloride from Tocris? Please let us know.
Reviews for PSB 11 hydrochloride
There are currently no reviews for this product. Be the first to review PSB 11 hydrochloride and earn rewards!
Have you used PSB 11 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.