PSB 0777 ammonium salt

Pricing Availability   Qty
Description: Potent adenosine A2A agonist
Chemical Name: 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt
Purity: ≥97% (HPLC)
Citations (2)
Literature (1)

Biological Activity for PSB 0777 ammonium salt

PSB 0777 ammonium salt is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.

Compound Libraries for PSB 0777 ammonium salt

PSB 0777 ammonium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 0777 ammonium salt

M. Wt 500.55
Formula C18H20N5O7S2.NH4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 2122196-16-9
PubChem ID 90488932
Smiles NC1=C3C(N([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)C=N3)=NC(SCCC2=CC=C(S(=O)(O)=O)C=C2)=N1.N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSB 0777 ammonium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 50.05 100
DMSO 50.05 100

Preparing Stock Solutions for PSB 0777 ammonium salt

The following data is based on the product molecular weight 500.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets for PSB 0777 ammonium salt

Certificate of Analysis / Product Datasheet
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References for PSB 0777 ammonium salt

References are publications that support the biological activity of the product.

El-Tayeb et al (2012) Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists. ACS Med.Chem.Lett. 2 890 PMID: 24900277

If you know of a relevant reference for PSB 0777 ammonium salt, please let us know.

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2 Citations for PSB 0777 ammonium salt

Citations are publications that use Tocris products. Selected citations for PSB 0777 ammonium salt include:

Gemma et al (2020) Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Comput Struct Biotechnol J 18 2723-2732 PMID: 33101610

Cezary et al (2020) Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y12 Antagonists in a cAMP- and Calcium-Dependent Manner. Pharmaceuticals (Basel) 13 PMID: 32752089

Do you know of a great paper that uses PSB 0777 ammonium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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