PSB 0777 ammonium salt

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Cat.No. 4334 - PSB 0777 ammonium salt | C18H20N5O7S2.NH4
Description: Potent adenosine A2A agonist
Chemical Name: 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.

Technical Data

M. Wt 500.55
Formula C18H20N5O7S2.NH4
Storage Store at RT
Purity ≥98% (HPLC)
PubChem ID 90488932
InChI Key AYQGFWKUGKSGCZ-VSAOVUCUSA-N
Smiles NC1=C3C(N([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)C=N3)=NC(SCCC2=CC=C(S(=O)(O)=O)C=C2)=N1.N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.05 100
water 50.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 500.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

El-Tayeb et al (2012) Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists. ACS Med.Chem.Lett. 2 890 PMID:


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Keywords: Adenosine A2A receptors agonists potent subtypes selective PSB0777 ammonium salt Adenosine A2A Receptors

Citations for PSB 0777 ammonium salt

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Literature in this Area

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Pathways for PSB 0777 ammonium salt

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