Proxyfan oxalate

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Cat.No. 2477 - Proxyfan oxalate | C13H16N2O.C2H2O4 | CAS No. 177708-09-7
Description: High affinity H3 ligand
Chemical Name: 4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

High affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. In functional studies, activity ranges from full agonist to inverse agonist depending on system used. Displays partial agonist effects on cAMP inhibition and MAPK activity, neutral antagonist activity on histamine release and partial inverse agonism of [3H]-arachidonic acid release.

Compound Libraries

Proxyfan oxalate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 306.32
Formula C13H16N2O.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 177708-09-7
PubChem ID 76900838
InChI Key QVMZCQMJBQSPSW-UHFFFAOYSA-N
Smiles OC(=O)C(O)=O.C(COCC1=CC=CC=C1)CC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.24 100
water 33.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 306.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.65 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Baldi et al (2005) The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Neuropharmacology 48 246 PMID: 15695163

Krueger et al (2005) G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J.Pharmacol.Exp.Ther 314 271 PMID: 15821027

Gbahou et al (2003) Protean agonism at histamine H3 receptors in vitro and in vivo. Proc.Natl.Acad.Sci.USA 100 11086 PMID:


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Keywords: Proxyfan oxalate, supplier, High, affinity, H3, ligands, Receptors, Histamine, histaminergic, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience

1 Citation for Proxyfan oxalate

Citations are publications that use Tocris products. Selected citations for Proxyfan oxalate include:

Singh et al (2012) Development of time-resolved fluorescent based [EU]-GTP binding assay for selection of human Histamine 3 receptor antagonists/inverse agonist: a potential target for Alzheimer's treatment. Ann Neurosci 19 71 PMID: 25205969


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