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Biological Activity for Pronethalol hydrochloride
Pronethalol hydrochloride is an β-adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias.
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for Pronethalol hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pronethalol hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pronethalol hydrochloride
The following data is based on the product molecular weight 265.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.76 mL||18.81 mL||37.63 mL|
|5 mM||0.75 mL||3.76 mL||7.53 mL|
|10 mM||0.38 mL||1.88 mL||3.76 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
Product Datasheets for Pronethalol hydrochloride
References for Pronethalol hydrochloride
References are publications that support the biological activity of the product.
Main (1990) α-Adrenergic receptors. Comprehensive Medicinal Chemistry. Ed Hansch 3 187
Merck Index 12 7974
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1 Citation for Pronethalol hydrochloride
Citations are publications that use Tocris products. Selected citations for Pronethalol hydrochloride include:
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.