Proglumide sodium salt

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Cat.No. 1478 - Proglumide sodium salt | C18H25N2NaO4 | CAS No. 99247-33-3
Description: Non-selective CCK antagonist; orally active
Chemical Name: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
Purity: ≥99% (HPLC)

Biological Activity

Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.

Technical Data

M. Wt 356.39
Formula C18H25N2NaO4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 99247-33-3
PubChem ID 23677833
Smiles [Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 35.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 356.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Iwamoto et al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53 PMID: 6202584

Mauss et al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215 PMID: 8166452

Hahne et al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304 PMID: 6171817

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