Discontinued Product

Probucol (Cat. No. 2775) has been withdrawn from sale for commercial reasons.
Description: ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Probucol

Probucol is an ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.

Technical Data for Probucol

M. Wt 516.84
Formula C31H48O2S2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23288-49-5
PubChem ID 4912
Smiles CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Probucol

Certificate of Analysis / Product Datasheet
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Keywords: Probucol, Probucol supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, ATP-binding, cassette, ABCA1, CERP, Antioxidants, Multidrug, Transporters, 2775, Tocris Bioscience

1 Citation for Probucol

Citations are publications that use Tocris products. Selected citations for Probucol include:

Guo et al (2016) VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun 7 12646 PMID: 27561680

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Literature in this Area

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