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Cat.No. 2775 - Probucol | C31H48O2S2 | CAS No. 23288-49-5
Description: ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity

ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.

Technical Data

M. Wt 516.84
Formula C31H48O2S2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23288-49-5
PubChem ID 4912
Smiles CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.92 25
ethanol 51.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 516.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.35 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Ruixing et al (2006) Pretreatment with prob. attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549 PMID: 17101546

Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477 PMID: 17293560

Favari et al (2004) Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler.Thromb.Vasc.Biol. 24 2345 PMID: 15514211

Wu et al (2004) Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J.Biol.Chem. 279 30168 PMID: 15140889

If you know of a relevant reference for Probucol, please let us know.

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Keywords: Probucol, Probucol supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, ATP-binding, cassette, ABCA1, CERP, Antioxidants, Multidrug, Transporters, 2775, Tocris Bioscience

1 Citation for Probucol

Citations are publications that use Tocris products. Selected citations for Probucol include:

Guo et al (2016) VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nat Commun 7 12646 PMID: 27561680

Do you know of a great paper that uses Probucol from Tocris? Please let us know.

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Literature in this Area

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