Probucol

Pricing Availability Delivery Time Qty
Cat.No. 2775 - Probucol | C31H48O2S2 | CAS No. 23288-49-5
Description: Antioxidant, anti-inflammatory and hypocholesterolemic agent
Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

Technical Data

M. Wt 516.84
Formula C31H48O2S2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23288-49-5
PubChem ID 4912
InChI Key FYPMFJGVHOHGLL-UHFFFAOYSA-N
Smiles CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.92 25
ethanol 51.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 516.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.35 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ku et al (1990) Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties. FASEB J. 4 1645 PMID: 2318380

Ruixing et al (2006) Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549 PMID: 17101546

Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477 PMID: 17293560


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Keywords: Probucol, supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, Antioxidants, Antioxidants, Tocris Bioscience

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