Pricing Availability Delivery Time Qty
Cat.No. 2775 - Probucol | C31H48O2S2 | CAS No. 23288-49-5
Description: Antioxidant, anti-inflammatory and hypocholesterolemic agent
Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity: ≥99% (HPLC)

Biological Activity

Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

Technical Data

M. Wt 516.84
Formula C31H48O2S2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23288-49-5
PubChem ID 4912
Smiles CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.92 25
ethanol 51.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 516.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.35 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Ku et al (1990) Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties. FASEB J. 4 1645 PMID: 2318380

Ruixing et al (2006) Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549 PMID: 17101546

Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477 PMID: 17293560

If you know of a relevant reference for Probucol, please let us know.

View Related Products by Target

Keywords: Probucol, supplier, Antioxidant, anti-inflammatory, hypocholesterolemic, hypocholesterolaemic, agent, Antioxidants, Antioxidants, Tocris Bioscience

Citations for Probucol

Citations are publications that use Tocris products.

Currently there are no citations for Probucol. Do you know of a great paper that uses Probucol from Tocris? If so please let us know.

Reviews for Probucol

There are currently no reviews for this product. Be the first to review Probucol and earn rewards!

Have you used Probucol?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells