PQ 69

Discontinued Product

PQ 69 (Cat. No. 5351) has been withdrawn from sale for commercial reasons.
Description: Potent and selective A1 inverse agonist
Chemical Name: 4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98% (HPLC)

Biological Activity for PQ 69

PQ 69 is a potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.

Technical Data for PQ 69

M. Wt 350.39
Formula C20H19FN4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 910045-32-8
PubChem ID 121513859
Smiles O=C1N(C4=CC(F)=CC=C4)NC2=C1C(NCCCC)=NC3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PQ 69

References are publications that support the biological activity of the product.

Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619 PMID: 25248972

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Keywords: PQ 69, PQ 69 supplier, PQ69, Potent, selective, A1, antagonists, receptors, adenosines, inverse, agonists, Adenosine, Receptors, 5351, Tocris Bioscience

Citations for PQ 69

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Currently there are no citations for PQ 69.

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