PQ 401

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Description: IGF1R inhibitor
Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Purity: ≥99% (HPLC)
Citations (5)
Literature (2)
Pathways (1)

Biological Activity for PQ 401

PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.

Compound Libraries for PQ 401

PQ 401 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PQ 401

M. Wt 341.79
Formula C18H16ClN3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 196868-63-0
PubChem ID 9549305
Smiles O=C(NC3=C(OC)C=CC(Cl)=C3)NC2=CC(C)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PQ 401

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.09 50
ethanol 8.54 25

Preparing Stock Solutions for PQ 401

The following data is based on the product molecular weight 341.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.85 mL 29.26 mL 58.52 mL
2.5 mM 1.17 mL 5.85 mL 11.7 mL
5 mM 0.59 mL 2.93 mL 5.85 mL
25 mM 0.12 mL 0.59 mL 1.17 mL

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References for PQ 401

References are publications that support the biological activity of the product.

Anderson et al (2006) Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor. J.Comb.Chem. 8 784 PMID: 16961415

Sivakumar et al (2009) Autocrine loop for IGF-I receptor signaling in SLUG-mediated epithelial-mesenchymal transition. 34 329 PMID: 19148466

Gable et al (2006) Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 5 1079 PMID: 16648580

If you know of a relevant reference for PQ 401, please let us know.

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Keywords: PQ 401, PQ 401 supplier, IGF-IR, inhibitors, inhibits, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, PQ401, Insulin, and, insulin-like, 2768, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for PQ 401

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.