Potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||8.77||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 438.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.4 mL||57.02 mL||114.03 mL|
|1 mM||2.28 mL||11.4 mL||22.81 mL|
|2 mM||1.14 mL||5.7 mL||11.4 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
References are publications that support the biological activity of the product.
Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447 PMID: 19785436
Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553 PMID: 23520314
If you know of a relevant reference for PPQ 102, please let us know.
View Related Products by Product Action
Keywords: PPQ 102, PPQ 102 supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, 4303, Tocris Bioscience
Citations for PPQ 102
Citations are publications that use Tocris products.
Currently there are no citations for PPQ 102. Do you know of a great paper that uses PPQ 102 from Tocris? Please let us know.
Reviews for PPQ 102
There are currently no reviews for this product. Be the first to review PPQ 102 and earn rewards!
Have you used PPQ 102?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.