PPQ 102

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Cat.No. 4303 - PPQ 102 | C26H22N4O3 | CAS No. 931706-15-9
Description: Potent, voltage-independent CFTR chloride channel inhibitor
Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.

Technical Data

M. Wt 438.48
Formula C26H22N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 931706-15-9
PubChem ID 16016583
InChI Key MNOOVRNGPIWJDI-UHFFFAOYSA-N
Smiles O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.77 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 438.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.4 mL 57.02 mL 114.03 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
2 mM 1.14 mL 5.7 mL 11.4 mL
10 mM 0.23 mL 1.14 mL 2.28 mL

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References

References are publications that support the biological activity of the product.

Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447 PMID: 19785436

Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553 PMID: 23520314


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Literature in this Area

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels