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PPQ 102

Cat. No. 4303 1 Review Submit a Review Datasheet / COA / SDS
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Description: Potent, voltage-independent CFTR chloride channel inhibitor
Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PPQ 102

PPQ 102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.

Technical Data for PPQ 102

M. Wt 438.48
Formula C26H22N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 931706-15-9
PubChem ID 16016583
InChI Key MNOOVRNGPIWJDI-UHFFFAOYSA-N
Smiles O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PPQ 102

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.77 20 with gentle warming

Preparing Stock Solutions for PPQ 102

The following data is based on the product molecular weight 438.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.4 mL 57.02 mL 114.03 mL
1 mM 2.28 mL 11.4 mL 22.81 mL
2 mM 1.14 mL 5.7 mL 11.4 mL
10 mM 0.23 mL 1.14 mL 2.28 mL

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References for PPQ 102

References are publications that support the biological activity of the product.

Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447 PMID: 19785436

Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553 PMID: 23520314

If you know of a relevant reference for PPQ 102, please let us know.

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Keywords: PPQ 102, PPQ 102 supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, 4303, Tocris Bioscience

Citations for PPQ 102

Citations are publications that use Tocris products.

Currently there are no citations for PPQ 102. Do you know of a great paper that uses PPQ 102 from Tocris? Please let us know.

Reviews for PPQ 102

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PPQ 102 inhibited of CFTR chloride current was studied.
By Lutpine Rachel on 01/16/2020
Species: Human

PPQ-102 inhibited of CFTR chloride current was studied.Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state.

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Literature in this Area

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