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Submit ReviewPPQ 102
Description: Potent, voltage-independent CFTR chloride channel inhibitor
Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
Purity: ≥98% (HPLC)
Biological Activity for PPQ 102
PPQ 102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.
Technical Data for PPQ 102
| M. Wt | 438.48 |
| Formula | C26H22N4O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 931706-15-9 |
| PubChem ID | 16016583 |
| InChI Key | MNOOVRNGPIWJDI-UHFFFAOYSA-N |
| Smiles | O=C(N2C)C1=C(C3=CC=CC=C3)N4C(C(C6=CC=C(C)O6)NC5=C4C=CC=C5)=C1N(C)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PPQ 102
References for PPQ 102
References are publications that support the biological activity of the product.
Tradtrantip et al (2009) Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J.Med.Chem. 52 6447 PMID: 19785436
Martin et al (2013) CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium. Eur.Resp.J. 42 1553 PMID: 23520314
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Keywords: PPQ 102, PPQ 102 supplier, PPQ102, potent, voltage, independent, CFTR, chloride, channel, inhibitors, inhibits, cystic, fibrosis, transmembrane, conductance, 4303, Tocris Bioscience
Citations for PPQ 102
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Currently there are no citations for PPQ 102.
Reviews for PPQ 102
Average Rating: 5 (Based on 1 Review.)
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PPQ 102 inhibited of CFTR chloride current was studied.
By
Lutpine Rachel on 01/16/2020
Species: Human
PPQ-102 inhibited of CFTR chloride current was studied.Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state.
