PPDA

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Cat.No. 2530 - PPDA | C21H18N2O5 | CAS No. 684283-16-7
Description: Subtype-selective NR2C/NR2D antagonist
Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for NR2C, NR2D, NR2B and NR2A subunits respectively).

Licensing Information

Sold under license from UNeMed Corporation.

Technical Data

M. Wt 378.38
Formula C21H18N2O5
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 684283-16-7
PubChem ID 90488770
InChI Key FAQARVDXAFZICA-QVUSPSOHSA-N
Smiles O=C(C2=CC=C3C(C=CC4=C3C=CC=C4)=C2)N1[C@@H]([C@](O)=O)[C@@H]([C@](O)=O)NCC1.O=C(C6=CC=C7C(C=CC8=C7C=CC=C8)=C6)N5[C@H](C(O)=O)[C@H](C(O)=O)NCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq. NaOH 18.92 50
DMSO 37.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 378.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Feng et al (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 141 508 PMID: 14718249

Morley et al (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 48 2627 PMID: 15801853

Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066 PMID: 15743930


If you know of a relevant reference for PPDA, please let us know.

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Keywords: PPDA, supplier, Subtype-selective, NR2C/NR2D, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, cis-ppda, NMDA, Receptors, Tocris Bioscience

2 Citations for PPDA

Citations are publications that use Tocris products. Selected citations for PPDA include:

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Autophagy 7 62 PMID: 25071439

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647


Do you know of a great paper that uses PPDA from Tocris? If so please let us know.

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Pathways for PPDA

Protocols

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