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Submit ReviewPPAHV
Description: TRPV agonist
Alternative Names: Phorbol 12-phenylacetate 13-acetate 20-homovanillate
Chemical Name: [(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-1,1,6,8-tetramethyl-5-oxo-9-[phenylacetyl)oxy]-1H-cyclopropa[3,4]benz[1,2-e]azulen-3-yl]methyl ester benzeneacetic acid
Purity: ≥98% (HPLC)
Biological Activity for PPAHV
PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding. Induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo.
Technical Data for PPAHV
| M. Wt | 688.77 |
| Formula | C39H44O11 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 175796-50-6 |
| PubChem ID | 3035862 |
| InChI Key | OGRGWTXWAZBJKF-JXWJAAHMSA-N |
| Smiles | O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=CC(OC)=C(O)C=C5)=O)=C[C@]3([H])[C@@](O)2[C@H](C)[C@@H](OC(CC6=CC=CC=C6)=O)[C@]4(OC(C)=O)[C@]([H])3C(C)4C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PPAHV
References for PPAHV
References are publications that support the biological activity of the product.
Griffiths et al (2000) Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb. Br.J.Pharmacol. 131 1408 PMID: 11090114
Macho et al (2000) Phorboid 20-homovanillates induce apoptosis through a VR1-independent mechanism. Chem.Biol. 7 483 PMID: 10903936
Szallasi et al (1996) A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. Eur.J.Pharmacol. 299 221 PMID: 8901026
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Keywords: PPAHV, PPAHV supplier, Non-pungent, vanilloid, receptor, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Phorbol12, phenylacetate13, acetate20, homovanillate, Phorbol, 12-phenylacetate, 13-acetate, 20-homovanillate, 1466, Tocris Bioscience
Citations for PPAHV
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