Pomalidomide 4'-alkylC4-acid

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Cat.No. 7209 - Pomalidomide 4'-alkylC4-acid | C18H19N3O6 | CAS No. 2225940-48-5
Description: Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Chemical Name: 5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentanoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 373.37
Formula C18H19N3O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2225940-48-5
PubChem ID 139331580
InChI Key JUPYDAIBDNUUIF-UHFFFAOYSA-N
Smiles OC(CCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.34 100
DMF 37.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 373.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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References

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Keywords: Pomalidomide 4'-alkylC4-acid, Pomalidomide 4'-alkylC4-acid supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, AlkylC4, linker, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7209, Tocris Bioscience

Citations for Pomalidomide 4'-alkylC4-acid

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Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia