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Biological Activity for Pomalidomide 4'-alkylC4-acid
Pomalidomide 4'-alkylC4-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for Pomalidomide 4'-alkylC4-acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for Pomalidomide 4'-alkylC4-acid
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pomalidomide 4'-alkylC4-acid
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pomalidomide 4'-alkylC4-acid
The following data is based on the product molecular weight 373.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.68 mL||13.39 mL||26.78 mL|
|5 mM||0.54 mL||2.68 mL||5.36 mL|
|10 mM||0.27 mL||1.34 mL||2.68 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
Product Datasheets for Pomalidomide 4'-alkylC4-acid
References for Pomalidomide 4'-alkylC4-acid
References are publications that support the biological activity of the product.
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Keywords: Pomalidomide 4'-alkylC4-acid, Pomalidomide 4'-alkylC4-acid supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, AlkylC4, linker, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7209, Tocris Bioscience
Citations for Pomalidomide 4'-alkylC4-acid
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Custom Degrader Services
- Ubiquitin-Proteasome System Proteins and Assays
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia