Pomalidomide 4'-alkylC4-acid

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Description: Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Chemical Name: 5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentanoic acid
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for Pomalidomide 4'-alkylC4-acid

Pomalidomide 4'-alkylC4-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for Pomalidomide 4'-alkylC4-acid

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Pomalidomide 4'-alkylC4-acid

M. Wt 373.37
Formula C18H19N3O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2225940-48-5
PubChem ID 139331580
Smiles OC(CCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pomalidomide 4'-alkylC4-acid

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.34 100
DMF 37.34 100

Preparing Stock Solutions for Pomalidomide 4'-alkylC4-acid

The following data is based on the product molecular weight 373.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for Pomalidomide 4'-alkylC4-acid

References for Pomalidomide 4'-alkylC4-acid

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Keywords: Pomalidomide 4'-alkylC4-acid, Pomalidomide 4'-alkylC4-acid supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, AlkylC4, linker, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7209, Tocris Bioscience

Citations for Pomalidomide 4'-alkylC4-acid

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia