You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
(+)-SK&F 10047 hydrochloride
Biological Activity for (+)-SK&F 10047 hydrochloride
(+)-SK&F 10047 hydrochloride is a prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
Technical Data for (+)-SK&F 10047 hydrochloride
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (+)-SK&F 10047 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (+)-SK&F 10047 hydrochloride
The following data is based on the product molecular weight 293.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||17.02 mL||34.03 mL|
|5 mM||0.68 mL||3.4 mL||6.81 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
Product Datasheets for (+)-SK&F 10047 hydrochloride
References for (+)-SK&F 10047 hydrochloride
References are publications that support the biological activity of the product.
Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149 PMID: 8874133
Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200 PMID: 8535837
Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355 PMID: 1964225
If you know of a relevant reference for (+)-SK&F 10047 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: (+)-SK&F 10047 hydrochloride, (+)-SK&F 10047 hydrochloride supplier, σ1, sigma1, selective, agonists, Receptors, σ, sigma, (+)-SK&F10047, SK&F10047, hydrochloride, SKF10047, (+)-SK&F, 10047, SK&F10047, Sigma1, 1079, Tocris Bioscience
5 Citations for (+)-SK&F 10047 hydrochloride
Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943 PMID: 24485144
Brailoiu et al (2019) Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors. Cell Rep 26 330 PMID: 30625315
Amer et al (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol 168 1445 PMID: 23121507
Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458 PMID: 26461475
Kasaharaa et al (2016) The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes Neuroscience 340 176 PMID: 27815022
Do you know of a great paper that uses (+)-SK&F 10047 hydrochloride from Tocris? Please let us know.
Reviews for (+)-SK&F 10047 hydrochloride
There are currently no reviews for this product. Be the first to review (+)-SK&F 10047 hydrochloride and earn rewards!
Have you used (+)-SK&F 10047 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image