(+)-SK&F 10047 hydrochloride

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Cat.No. 1079 - (+)-SK&F 10047 hydrochloride | C17H23NO.HCl | CAS No. 133005-41-1
Description: σ1 selective agonist
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity

Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data

M. Wt 293.84
Formula C17H23NO.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 133005-41-1
PubChem ID 16759596
Smiles OC1=CC=C2C([C@@](CC3)(C)[C@H](C)[C@@H](N3CC=C)C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.38 100
water 29.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 17.02 mL 34.03 mL
5 mM 0.68 mL 3.4 mL 6.81 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via dopaminergic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149 PMID: 8874133

Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200 PMID: 8535837

Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355 PMID: 1964225

If you know of a relevant reference for (+)-SK&F 10047 hydrochloride, please let us know.

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3 Citations for (+)-SK&F 10047 hydrochloride

Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:

Kasaharaa et al (2016) The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes Neuroscience 340 176 PMID: 27815022

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458 PMID: 26461475

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943 PMID: 24485144

Do you know of a great paper that uses (+)-SK&F 10047 hydrochloride from Tocris? If so please let us know.

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