(+)-SK&F 10047 hydrochloride

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Cat.No. 1079 - (+)-SK&F 10047 hydrochloride | C17H23NO.HCl | CAS No. 133005-41-1
Description: σ1 selective agonist
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity

Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data

M. Wt 293.84
Formula C17H23NO.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 133005-41-1
PubChem ID 16759596
InChI Key ZTGMHFIGNYXMJV-XSCGHNKWSA-N
Smiles Cl.C[C@@H]1[C@@H]2CC3=CC=C(O)C=C3[C@@]1(C)CCN2CC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 29.38 100
DMSO 29.38 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 17.02 mL 34.03 mL
5 mM 0.68 mL 3.4 mL 6.81 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149 PMID: 8874133

Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200 PMID: 8535837

Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355 PMID: 1964225


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5 Citations for (+)-SK&F 10047 hydrochloride

Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:

Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458 PMID: 26461475

Amer et al (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol 168 1445 PMID: 23121507

Brailoiu et al (2019) Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors. Cell Rep 26 330 PMID: 30625315

Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943 PMID: 24485144


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