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(+)-SK&F 10047 hydrochloride
Prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 293.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||17.02 mL||34.03 mL|
|5 mM||0.68 mL||3.4 mL||6.81 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Kamei et al (1996) (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites. Eur.J.Pharmacol. 309 149 PMID: 8874133
Matsuno et al (1995) Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 690 200 PMID: 8535837
Walker et al (1990) Sigma receptors: biology and function. Pharmacol.Rev. 42 355 PMID: 1964225
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5 Citations for (+)-SK&F 10047 hydrochloride
Citations are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:
Kasaharaa et al (2016) The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes Neuroscience 340 176 PMID: 27815022
Amer et al (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol 168 1445 PMID: 23121507
Rodríguez-Muñoz et al (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol 6 35458 PMID: 26461475
Brailoiu et al (2019) Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors. Cell Rep 26 330 PMID: 30625315
Sánchez-Blázquez et al (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One 17 1943 PMID: 24485144
Do you know of a great paper that uses (+)-SK&F 10047 hydrochloride from Tocris? Please let us know.
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