(+)-JQ1 PA

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Cat.No. 6589 - (+)-JQ1 PA | C22H20ClN5OS | CAS No. 2115701-93-2
Description: Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499). Can be used as a precursor to PROTACs that target BET bromodomains. Supplied with an alkyne functionalized handle for click conjugation to a linker/E3 ligase ligand. Can also be conjugated to fluorescent dyes for imaging aplications.

Technical Data

M. Wt 437.95
Formula C22H20ClN5OS
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2115701-93-2
Smiles O=C(NCC#C)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C1=NN=C4C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.8 100
ethanol 43.8 100

Preparing Stock Solutions

The following data is based on the product molecular weight 437.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Tyler et al (2017) Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science 356 1397 PMID: 28619718


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Citations for (+)-JQ1 PA

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New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

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