(+)-Fluprostenol

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Cat.No. 4542 - (+)-Fluprostenol | C23H29F3O6 | CAS No. 54276-17-4
Description: High affinity FP prostaglandin receptor agonist
Alternative Names: Travoprost acid
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.

Technical Data

M. Wt 458.47
Formula C23H29F3O6
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 54276-17-4
PubChem ID 5311100
InChI Key WWSWYXNVCBLWNZ-QIZQQNKQSA-N
Smiles O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 458.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kelly et al (2003) Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 304 238 PMID: 12490597

Sharif et al (2003) Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 44 715 PMID: 12556403


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Keywords: Travoprost acid prostaglandin F2alpha F2a F2α receptors agonists Travoprost acid Prostanoid Receptors

Citations for (+)-Fluprostenol

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