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Discontinued Product(+)-Fluprostenol (Cat. No. 4542) has been withdrawn from sale for commercial reasons.
Biological Activity for (+)-Fluprostenol
(+)-Fluprostenol is a prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.
Technical Data for (+)-Fluprostenol
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (+)-Fluprostenol
References for (+)-Fluprostenol
References are publications that support the biological activity of the product.
Kelly et al (2003) Real-time intracellular Ca2+ mobilization by travo. acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 304 238 PMID: 12490597
Sharif et al (2003) Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 44 715 PMID: 12556403
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Keywords: (+)-Fluprostenol, (+)-Fluprostenol supplier, Travoprost, acid, prostaglandin, F2alpha, F2a, F2α, receptors, agonists, Prostanoid, Receptors, 4542, Tocris Bioscience
Citations for (+)-Fluprostenol
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Currently there are no citations for (+)-Fluprostenol.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.