Prostaglandin F2α (FP) receptor agonist (Ki = 49.9 nM; EC50 = 2.4 nM). Stimulates intracellular calcium mobilization in cloned human ocular FP receptors, rat A7r5 cells and mouse 3T3 cells (EC50 values are 17.5, 19.1 and 37.3 nM respectively). Analog of prostaglandin F2α. Isopropyl ester travaprost (Cat. No. 4218) also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 458.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.18 mL||10.91 mL||21.81 mL|
|5 mM||0.44 mL||2.18 mL||4.36 mL|
|10 mM||0.22 mL||1.09 mL||2.18 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kelly et al (2003) Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat and cloned human FP prostaglandin receptors. J.Pharmacol.Exp.Ther. 304 238 PMID: 12490597
Sharif et al (2003) Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other EP prostaglandin receptor agonist analogues. Invest.Ophthalmol.Vis.Sci. 44 715 PMID: 12556403
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Keywords: Travoprost acid prostaglandin F2alpha F2a F2α receptors agonists Travoprost acid Prostanoid Receptors
Citations for (+)-Fluprostenol
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Literature in this Area
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