Travaprost

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Cat.No. 4218 - Travaprost | C26H35F3O6 | CAS No. 157283-68-6
Description: Potent and selective FP prostaglandin receptor agonist
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity

FP prostaglandin receptor agonist. Exhibits submicromolar affinity for DP, EP, IP and TP receptors. Stimulates intracellular Ca2+ mobilization. Ocular hypotensive agent.

Technical Data

M. Wt 500.55
Formula C26H35F3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 157283-68-6
PubChem ID 5282226
InChI Key MKPLKVHSHYCHOC-AHTXBMBWSA-N
Smiles O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hellberg et al (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J.Ocul.Pharmacol.Ther. 17 421 PMID: 11765147

Sharif et al (1999) [3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travo. (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor. J.Pharm.Pharmacol. 51 685 PMID: 10454045


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Citations for Travaprost

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Literature in this Area

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