FP prostaglandin receptor agonist. Exhibits submicromolar affinity for DP, EP, IP and TP receptors. Stimulates intracellular Ca2+ mobilization. Ocular hypotensive agent.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 500.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2 mL||9.99 mL||19.98 mL|
|5 mM||0.4 mL||2 mL||4 mL|
|10 mM||0.2 mL||1 mL||2 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hellberg et al (2001) Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J.Ocul.Pharmacol.Ther. 17 421 PMID: 11765147
Sharif et al (1999) [3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor. J.Pharm.Pharmacol. 51 685 PMID: 10454045
If you know of a relevant reference for Travaprost, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Travaprost, supplier, Supplier, Travoprost, FP, receptor, agonist, prostaglandin, F2a, F2alpha, prostaglandin, ocular, hypotensive, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
Citations for Travaprost
Citations are publications that use Tocris products.
Currently there are no citations for Travaprost. Do you know of a great paper that uses Travaprost from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.