(+)-AJ 76 hydrochloride

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Cat.No. 0678 - (+)-AJ 76 hydrochloride | C15H23NO.HCl | CAS No. 85378-82-1
Description: Antagonist; preferential action at D2-like autoreceptors
Chemical Name: (1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride
Literature (5)

Biological Activity

Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).

Technical Data

M. Wt 269.81
Formula C15H23NO.HCl
Storage Store at RT
CAS Number 85378-82-1
PubChem ID 13755572
Smiles Cl.CCCN[C@@H]1CCC2=C(OC)C=CC=C2[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 10

Preparing Stock Solutions

The following data is based on the product molecular weight 269.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.06 mL 185.32 mL 370.63 mL
0.5 mM 7.41 mL 37.06 mL 74.13 mL
1 mM 3.71 mL 18.53 mL 37.06 mL
5 mM 0.74 mL 3.71 mL 7.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists. J.Med.Chem. 30 602 PMID: 3560156

Kullingsjo et al (1991) Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241 PMID: 1817961

Millan et al (2004) The role of DA D3 compared with DA D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341 PMID: 14985929

Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo. Eur.J.Pharmacol. 251 181 PMID: 8149975

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