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(+)-AJ 76 hydrochloride
Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 269.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||37.06 mL||185.32 mL||370.63 mL|
|0.5 mM||7.41 mL||37.06 mL||74.13 mL|
|1 mM||3.71 mL||18.53 mL||37.06 mL|
|5 mM||0.74 mL||3.71 mL||7.41 mL|
References are publications that support the biological activity of the product.
Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists. J.Med.Chem. 30 602 PMID: 3560156
Kullingsjo et al (1991) Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241 PMID: 1817961
Millan et al (2004) The role of DA D3 compared with DA D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341 PMID: 14985929
Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo. Eur.J.Pharmacol. 251 181 PMID: 8149975
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.