(+)-AJ 76 hydrochloride
Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 269.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.71 mL||18.53 mL||37.06 mL|
|5 mM||0.74 mL||3.71 mL||7.41 mL|
|10 mM||0.37 mL||1.85 mL||3.71 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the products' biological activity.
Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists. J.Med.Chem. 30 602 PMID: 3560156
Kullingsjo et al (1991) Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241 PMID: 1817961
Millan et al (2004) The role of dopamine D3 compared with dopamine D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341 PMID: 14985929
Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. Eur.J.Pharmacol. 251 181 PMID: 8149975
If you know of a relevant reference for (+)-AJ 76 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: (+)-AJ 76 hydrochloride, supplier, antagonists, preferential, action, D2-like, autoreceptors, Dopamine, Non-Selective, Receptors, dopaminergic, (+)-AJ76, hydrochloride, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
Citations for (+)-AJ 76 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (+)-AJ 76 hydrochloride. Do you know of a great paper that uses (+)-AJ 76 hydrochloride from Tocris? If so please let us know.
Reviews for (+)-AJ 76 hydrochloride
There are currently no reviews for this product. Be the first to review (+)-AJ 76 hydrochloride and earn rewards!
Have you used (+)-AJ 76 hydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.