PKUMDL WQ 2201

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Cat.No. 6581 - PKUMDL WQ 2201 | C15H14ClN3O3S | CAS No. 592474-91-4
Description: Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Technical Data

M. Wt 351.81
Formula C15H14ClN3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 592474-91-4
PubChem ID 5453153
InChI Key XPACBFAEZIPDRT-LSCVHKIXSA-N
Smiles CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046


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Citations for PKUMDL WQ 2201

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