You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PKUMDL WQ 2201
Biological Activity for PKUMDL WQ 2201
PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
Technical Data for PKUMDL WQ 2201
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PKUMDL WQ 2201
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PKUMDL WQ 2201
The following data is based on the product molecular weight 351.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.84 mL||14.21 mL||28.42 mL|
|5 mM||0.57 mL||2.84 mL||5.68 mL|
|10 mM||0.28 mL||1.42 mL||2.84 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References for PKUMDL WQ 2201
References are publications that support the biological activity of the product.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
If you know of a relevant reference for PKUMDL WQ 2201, please let us know.
View Related Products by Product Action
Keywords: PKUMDL WQ 2201, PKUMDL WQ 2201 supplier, PKUMDLWQ2201, PKUMDL-WQ-2201, PHGDH, 3-Phosphoglycerate, dehydrogenase, inhibitors, inhibits, negative, allosteric, modulators, anti-tumor, antitumor, NAM, Other, Dehydrogenases, 6581, Tocris Bioscience
Citations for PKUMDL WQ 2201
Citations are publications that use Tocris products.
Currently there are no citations for PKUMDL WQ 2201. Do you know of a great paper that uses PKUMDL WQ 2201 from Tocris? Please let us know.
Reviews for PKUMDL WQ 2201
There are currently no reviews for this product. Be the first to review PKUMDL WQ 2201 and earn rewards!
Have you used PKUMDL WQ 2201?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image