PKUMDL WQ 2201

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Description: Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for PKUMDL WQ 2201

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Technical Data for PKUMDL WQ 2201

M. Wt 351.81
Formula C15H14ClN3O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 592474-91-4
PubChem ID 5453153
InChI Key XPACBFAEZIPDRT-LSCVHKIXSA-N
Smiles CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKUMDL WQ 2201

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.18 100

Preparing Stock Solutions for PKUMDL WQ 2201

The following data is based on the product molecular weight 351.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets for PKUMDL WQ 2201

References for PKUMDL WQ 2201

References are publications that support the biological activity of the product.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046


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Keywords: PKUMDL WQ 2201, PKUMDL WQ 2201 supplier, PKUMDLWQ2201, PKUMDL-WQ-2201, PHGDH, 3-Phosphoglycerate, dehydrogenase, inhibitors, inhibits, negative, allosteric, modulators, anti-tumor, antitumor, NAM, Other, Dehydrogenases, 6581, Tocris Bioscience

Citations for PKUMDL WQ 2201

Citations are publications that use Tocris products.

Currently there are no citations for PKUMDL WQ 2201. Do you know of a great paper that uses PKUMDL WQ 2201 from Tocris? Please let us know.

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Literature in this Area

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.