Home / Pharmacology / Enzymes / Dehydrogenases / Other Dehydrogenases / Other Dehydrogenase Modulators / PKUMDL WQ 2101

PKUMDL WQ 2101

Cat. No. 6580 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PKUMDL WQ 2101

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

Technical Data for PKUMDL WQ 2101

M. Wt 317.25
Formula C14H11N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 304481-72-9
PubChem ID 6741780
InChI Key RABUUVVWWJCYEN-UHFFFAOYSA-N
Smiles OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKUMDL WQ 2101

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.73 100

Preparing Stock Solutions for PKUMDL WQ 2101

The following data is based on the product molecular weight 317.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for PKUMDL WQ 2101

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PKUMDL WQ 2101

References are publications that support the biological activity of the product.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046

If you know of a relevant reference for PKUMDL WQ 2101, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Modulators

Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience

Citations for PKUMDL WQ 2101

Citations are publications that use Tocris products.

Currently there are no citations for PKUMDL WQ 2101. Do you know of a great paper that uses PKUMDL WQ 2101 from Tocris? Please let us know.

Reviews for PKUMDL WQ 2101

There are currently no reviews for this product. Be the first to review PKUMDL WQ 2101 and earn rewards!

Have you used PKUMDL WQ 2101?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review