Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPKUMDL WQ 2101
Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Biological Activity for PKUMDL WQ 2101
PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
Technical Data for PKUMDL WQ 2101
| M. Wt | 317.25 |
| Formula | C14H11N3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 304481-72-9 |
| PubChem ID | 6741780 |
| InChI Key | RABUUVVWWJCYEN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PKUMDL WQ 2101
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 |
Preparing Stock Solutions for PKUMDL WQ 2101
The following data is based on the product molecular weight 317.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for PKUMDL WQ 2101
References for PKUMDL WQ 2101
References are publications that support the biological activity of the product.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
If you know of a relevant reference for PKUMDL WQ 2101, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience
Citations for PKUMDL WQ 2101
Citations are publications that use Tocris products.
Currently there are no citations for PKUMDL WQ 2101. Do you know of a great paper that uses PKUMDL WQ 2101 from Tocris? Please let us know.
Reviews for PKUMDL WQ 2101
There are currently no reviews for this product. Be the first to review PKUMDL WQ 2101 and earn rewards!
Have you used PKUMDL WQ 2101?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image