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Submit ReviewPKUMDL WQ 2101
Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Biological Activity
Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.
Technical Data
| M. Wt | 317.25 |
| Formula | C14H11N3O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 304481-72-9 |
| PubChem ID | 6741780 |
| InChI Key | RABUUVVWWJCYEN-UHFFFAOYSA-N |
| Smiles | OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 317.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046
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Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience
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