PKUMDL WQ 2101

Discontinued Product

6580 has been discontinued.

View all Other Dehydrogenases products.
Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for PKUMDL WQ 2101

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

Technical Data for PKUMDL WQ 2101

M. Wt 317.25
Formula C14H11N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 304481-72-9
PubChem ID 6741780
InChI Key RABUUVVWWJCYEN-UHFFFAOYSA-N
Smiles OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PKUMDL WQ 2101

References for PKUMDL WQ 2101

References are publications that support the biological activity of the product.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046

View Related Products by Target

View Related Products by Product Action

View all Other Dehydrogenase Modulators

Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience

1 Citation for PKUMDL WQ 2101

Citations are publications that use Tocris products. Selected citations for PKUMDL WQ 2101 include:

John M et al (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun 13 2698 PMID: 35577785


Reviews for PKUMDL WQ 2101

There are currently no reviews for this product. Be the first to review PKUMDL WQ 2101 and earn rewards!

Have you used PKUMDL WQ 2101?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.