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Description: Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for PKUMDL WQ 2101

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

Technical Data for PKUMDL WQ 2101

M. Wt 317.25
Formula C14H11N3O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 304481-72-9
PubChem ID 6741780
Smiles OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PKUMDL WQ 2101

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.73 100

Preparing Stock Solutions for PKUMDL WQ 2101

The following data is based on the product molecular weight 317.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets for PKUMDL WQ 2101

References for PKUMDL WQ 2101

References are publications that support the biological activity of the product.

Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID: 28042046

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Keywords: PKUMDL WQ 2101, PKUMDL WQ 2101 supplier, PKUMDLWQ2101, Phosphoglycerate, dehydrogenase, PHGDH, allosteric, inhibitor, serine, biosynthesis, negative, modulator, NAM, Other, Dehydrogenases, 6580, Tocris Bioscience

1 Citation for PKUMDL WQ 2101

Citations are publications that use Tocris products. Selected citations for PKUMDL WQ 2101 include:

John M et al (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun 13 2698 PMID: 35577785

Do you know of a great paper that uses PKUMDL WQ 2101 from Tocris? Please let us know.

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Literature in this Area

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