PKC ζ pseudosubstrate

Discontinued Product

PKC ζ pseudosubstrate (Cat. No. 1791) has been withdrawn from sale for commercial reasons.
Description: PKC ζ inhibitor peptide (attached to cell-permeable vector)
Alternative Names: Protein kinase C zeta pseudosubstrate
Datasheet
Citations (2)
Reviews

Biological Activity for PKC ζ pseudosubstrate

PKC ζ pseudosubstrate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.

Technical Data for PKC ζ pseudosubstrate

M. Wt 4673.59
Formula C208H336N74O44S3
Sequence CRQIKIWFQNRRMKWKK CSIYRRGARRWRKLYRAN*

(Modifications: Disulfide bridge between 1 -1*)

Storage Store at -20°C
PubChem ID 90488711
InChI Key BQLVLLVGFUIFFK-OXSGATHOSA-N
Smiles [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PKC ζ pseudosubstrate

Certificate of Analysis / Product Datasheet
Select another batch:

References for PKC ζ pseudosubstrate

References are publications that support the biological activity of the product.

Laudanna et al (1998) Evidence of ζ protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306 PMID: 9804792

Lim et al (2008) A myristoylated pseudosubstrate peptide of PKC-ζ induces degranulation in HMC-1 cells independently of PKC-ζ activity. Life Sci. 82 733 PMID: 18289606

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

View Related Products by Target

View Related Products by Product Action

View all Protein Kinase C Inhibitors

Keywords: PKC z pseudosubstrate, PKC z pseudosubstrate supplier, PKC, zeta, inhibitors, inhibits, Protein, Kinases, C, pseudosubstrate, PKCz, ProteinkinaseC, kinase, Kinase, 1791, Tocris Bioscience

2 Citations for PKC ζ pseudosubstrate

Citations are publications that use Tocris products. Selected citations for PKC ζ pseudosubstrate include:

Mu et al (2011) TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun 2 330 PMID: 21629263

Mattson et al (2019) Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice. J Biol Chem PMID: 31189651


Reviews for PKC ζ pseudosubstrate

There are currently no reviews for this product. Be the first to review PKC ζ pseudosubstrate and earn rewards!

Have you used PKC ζ pseudosubstrate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review