Piribedil dihydrochloride

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Cat.No. 1031 - Piribedil dihydrochloride | C16H18N4O2.2HCl | CAS No. 1451048-94-4
Description: Dopamine agonist
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (5)

Biological Activity

A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.

Technical Data

M. Wt 371.27
Formula C16H18N4O2.2HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1451048-94-4
PubChem ID 3038520
Smiles Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 8.37 25

Preparing Stock Solutions

The following data is based on the product molecular weight 371.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.77 mL 53.87 mL 107.74 mL
1.25 mM 2.15 mL 10.77 mL 21.55 mL
2.5 mM 1.08 mL 5.39 mL 10.77 mL
12.5 mM 0.22 mL 1.08 mL 2.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Cagnotto et al (1996) In vitro affinity of piribedil for DA D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63 PMID: 8905329

Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2 PMID: 1634907

Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomor. and the 'atypical DA agonists' (piribedil and S36080). Life Sci. 38 895 PMID: 3081774

Merck Index 12 7648

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Keywords: Piribedil dihydrochloride, Piribedil dihydrochloride supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, 1031, Tocris Bioscience

1 Citation for Piribedil dihydrochloride

Citations are publications that use Tocris products. Selected citations for Piribedil dihydrochloride include:

Rodrigues et al (2014) Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar DArgic D2 activity after REM sleep deprivation. Front Cell Neurosci 8 383 PMID: 25520618

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.


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