Piribedil dihydrochloride

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Cat.No. 1031 - Piribedil dihydrochloride | C16H18N4O2.2HCl | CAS No. 1451048-94-4
Description: Dopamine agonist
Chemical Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.

Technical Data

M. Wt 371.27
Formula C16H18N4O2.2HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1451048-94-4
PubChem ID 3038520
InChI Key VRSRBPOCDOKYKT-UHFFFAOYSA-N
Smiles Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.37 25

Preparing Stock Solutions

The following data is based on the product molecular weight 371.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.47 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cagnotto et al (1996) In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63 PMID: 8905329

Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2 PMID: 1634907

Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S36080). Life Sci. 38 895 PMID: 3081774

Merck Index 12 7648 PMID:


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Keywords: Piribedil dihydrochloride, supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience

Citations for Piribedil dihydrochloride

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