PIM-1 Inhibitor 2

Pricing Availability Delivery Time Qty
Cat.No. 3589 - PIM-1 Inhibitor 2 | C17H11ClN4O | CAS No. 477845-12-8
Description: Pim-1 kinase inhibitor
Chemical Name: 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)

Biological Activity

Potent Pim-1 kinase inhibitor (Ki = 91 nM).

Compound Libraries

PIM-1 Inhibitor 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 322.75
Formula C17H11ClN4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 477845-12-8
PubChem ID 2765355
Smiles NC1=NC=CC(C3=CC2=C(C4=CC=C(Cl)C=C4)ON=C2C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.21 75

Preparing Stock Solutions

The following data is based on the product molecular weight 322.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.49 mL 30.98 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Pierce et al (2008) Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J.Med.Chem. 51 1972 PMID: 18290603

If you know of a relevant reference for PIM-1 Inhibitor 2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Pim Kinase Inhibitors

Keywords: Pim-1 kinase inhibitors inhibits kinases PIM-1 Inhibitor2 Pim Kinase

Citations for PIM-1 Inhibitor 2

Citations are publications that use Tocris products.

Currently there are no citations for PIM-1 Inhibitor 2. Do you know of a great paper that uses PIM-1 Inhibitor 2 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for PIM-1 Inhibitor 2


TODO: Add Protocols