PIM-1 Inhibitor 2

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Cat.No. 3589 - PIM-1 Inhibitor 2 | C17H11ClN4O | CAS No. 477845-12-8
Description: Pim-1 kinase inhibitor
Chemical Name: 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent Pim-1 kinase inhibitor (Ki = 91 nM).

Compound Libraries

PIM-1 Inhibitor 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 322.75
Formula C17H11ClN4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 477845-12-8
PubChem ID 2765355
InChI Key AQVFETGXIRKVAQ-UHFFFAOYSA-N
Smiles NC1=NC=CC(C3=CC2=C(C4=CC=C(Cl)C=C4)ON=C2C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.21 75

Preparing Stock Solutions

The following data is based on the product molecular weight 322.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.1 mL 15.49 mL 30.98 mL
5 mM 0.62 mL 3.1 mL 6.2 mL
10 mM 0.31 mL 1.55 mL 3.1 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pierce et al (2008) Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J.Med.Chem. 51 1972 PMID: 18290603


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Keywords: Pim-1 kinase inhibitors inhibits kinases PIM-1 Inhibitor2 Pim Kinase

Citations for PIM-1 Inhibitor 2

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Pathways for PIM-1 Inhibitor 2

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