PIM-1 Inhibitor 2

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Cat.No. 3589 - PIM-1 Inhibitor 2 | C17H11ClN4O | CAS No. 477845-12-8
Description: Pim-1 kinase inhibitor
Chemical Name: 4-[3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl]-2-pyrimidinamine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Potent Pim-1 kinase inhibitor (Ki = 91 nM).

Compound Libraries

PIM-1 Inhibitor 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 322.75
Formula C17H11ClN4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 477845-12-8
PubChem ID 2765355
Smiles NC1=NC=CC(C3=CC2=C(C4=CC=C(Cl)C=C4)ON=C2C=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.21 75

Preparing Stock Solutions

The following data is based on the product molecular weight 322.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.13 mL 20.66 mL 41.31 mL
3.75 mM 0.83 mL 4.13 mL 8.26 mL
7.5 mM 0.41 mL 2.07 mL 4.13 mL
37.5 mM 0.08 mL 0.41 mL 0.83 mL

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References are publications that support the biological activity of the product.

Pierce et al (2008) Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J.Med.Chem. 51 1972 PMID: 18290603

If you know of a relevant reference for PIM-1 Inhibitor 2, please let us know.

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1 Citation for PIM-1 Inhibitor 2

Citations are publications that use Tocris products. Selected citations for PIM-1 Inhibitor 2 include:

Yin et al (2013) Inhibition of the Pim1 oncogene results in diminished visual function. PLoS One 7 e52177 PMID: 23300608

Do you know of a great paper that uses PIM-1 Inhibitor 2 from Tocris? Please let us know.

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