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Biological Activity for Photo-lenalidomide-acid
Photo-lenalidomide-acid is a functionalized cereblon ligand containing a dimethoxy azo-benzene photoswitch; for use as a precursor to photoswitchable Degraders (PHOTACs). Photo-lenalidomide-acid is supplied with a carboxylic acid functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for Degrader R&D.
Usage Guidelines for Photo-lenalidomide-acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for Photo-lenalidomide-acid
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Photo-lenalidomide-acid
References for Photo-lenalidomide-acid
References are publications that support the biological activity of the product.
Reynders et al (2020) PHOTACs enable optical control of protein degradation. Sci.Adv. 6 eaay5064 PMID: 32128406
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Keywords: Photo-lenalidomide-acid, Photo-lenalidomide-acid supplier, PROTACs, degraders, building, blocks, photoswitchable, carboxylic, acid, functionalized, cereblon, e3, ligase, ligand, targeted, protein, degradation, tpd, Functionalized, E3, Ligase, Ligands, 7328, Tocris Bioscience
Citations for Photo-lenalidomide-acid
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia