Philanthotoxin 74

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Cat.No. 2770 - Philanthotoxin 74 | C24H42N4O3.2HCl | CAS No. 1227301-51-0
Description: GluA1 and GluA3 selective AMPA antagonist
Alternative Names: PhTx-74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (10)

Biological Activity for Philanthotoxin 74

Philanthotoxin 74 is an AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.

Technical Data for Philanthotoxin 74

M. Wt 507.54
Formula C24H42N4O3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1227301-51-0
PubChem ID 46213501

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Philanthotoxin 74

Solvent Max Conc. mg/mL Max Conc. mM
water 50.75 100
DMSO 50.75 100

Preparing Stock Solutions for Philanthotoxin 74

The following data is based on the product molecular weight 507.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for Philanthotoxin 74

Certificate of Analysis / Product Datasheet
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References for Philanthotoxin 74

References are publications that support the biological activity of the product.

Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902 PMID: 17391037

Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261 PMID: 24220009

If you know of a relevant reference for Philanthotoxin 74, please let us know.

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Keywords: Philanthotoxin 74, Philanthotoxin 74 supplier, GluR1/2, selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, Philanthotoxin74, PhTx74, homomeric, GluR3, GluR1, GluR2/3, GluA1, GluA2, GluA3, PhTx-74, 2770, Tocris Bioscience

2 Citations for Philanthotoxin 74

Citations are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:

Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900 PMID: 24983627

Zhao et al (2018) Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience 6 138 PMID: 30240608

Do you know of a great paper that uses Philanthotoxin 74 from Tocris? Please let us know.

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Literature in this Area

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