Philanthotoxin 74

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Cat.No. 2770 - Philanthotoxin 74 | C24H42N4O3.2HCl | CAS No. 1227301-51-0
Description: GluR1 and GluR3 AMPA receptor antagonist
Alternative Names: PhTx-74
Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

AMPA receptor antagonist. Non-selective homomeric GluR3 and GluR1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluR3 and GluR1 with a 100-fold greater potency than heteromeric GluR1/2 and GluR2/3 receptors.

Technical Data

M. Wt 507.54
Formula C24H42N4O3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1227301-51-0
PubChem ID 46213501
InChI Key HWTJQQMIKVJWLH-IKXQUJFKSA-N
Smiles OC1=CC=C(C[C@H](NC(CCC)=O)C(NCCCCCCCNCCCCN)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.75 100
water 50.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 507.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 129 4902 PMID: 17391037

Poulsen et al (2013) Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol.Pharmacol. 85 261 PMID: 24220009


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Keywords: GluR1/2 selective AMPA antagonists Glutamate Receptors iGluR Ionotropic Philanthotoxin74 PhTx74 homomeric GluR3 GluR1 GluR2/3 PhTx-74 AMPA Receptors

1 Citation for Philanthotoxin 74

Citations are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:

Kim and Ziff (2014) Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors. PLoS Biol 12 e1001900 PMID: 24983627


Do you know of a great paper that uses Philanthotoxin 74 from Tocris? If so please let us know.

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Pathways for Philanthotoxin 74

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