Phentolamine Mesylate

Pricing Availability   Qty
Description: Adrenergic α receptor antagonist; antihypertensive
Chemical Name: 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol methanesulfonate
Purity: ≥98% (HPLC)
Citations (2)
Literature (1)

Biological Activity for Phentolamine Mesylate

Phentolamine Mesylate is a non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.

Compound Libraries for Phentolamine Mesylate

Phentolamine Mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Phentolamine Mesylate

M. Wt 377.46
Formula C17H19N3O.CH4O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 65-28-1
PubChem ID 91430
Smiles CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Phentolamine Mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 37.75 100
DMSO 37.75 100

Preparing Stock Solutions for Phentolamine Mesylate

The following data is based on the product molecular weight 377.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for Phentolamine Mesylate

References for Phentolamine Mesylate

References are publications that support the biological activity of the product.

Liu & Coupar (1996) Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 117 787 PMID: 8851491

Fioretti et al (2017) Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 99 53 PMID: 28986330

Nonogaki & Kaji (2017) α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 18 35 PMID: 27939978

If you know of a relevant reference for Phentolamine Mesylate, please let us know.

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2 Citations for Phentolamine Mesylate

Citations are publications that use Tocris products. Selected citations for Phentolamine Mesylate include:

David R et al (2021) Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux. Front Oncol 10 614288 PMID: 33598432

Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823

Do you know of a great paper that uses Phentolamine Mesylate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.