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Biological Activity for Phentolamine Mesylate
Phentolamine Mesylate is a non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.
Compound Libraries for Phentolamine Mesylate
Technical Data for Phentolamine Mesylate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Phentolamine Mesylate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Phentolamine Mesylate
The following data is based on the product molecular weight 377.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.65 mL||13.25 mL||26.49 mL|
|5 mM||0.53 mL||2.65 mL||5.3 mL|
|10 mM||0.26 mL||1.32 mL||2.65 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
Product Datasheets for Phentolamine Mesylate
References for Phentolamine Mesylate
References are publications that support the biological activity of the product.
Liu & Coupar (1996) Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 117 787 PMID: 8851491
Fioretti et al (2017) Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 99 53 PMID: 28986330
Nonogaki & Kaji (2017) α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 18 35 PMID: 27939978
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2 Citations for Phentolamine Mesylate
Citations are publications that use Tocris products. Selected citations for Phentolamine Mesylate include:
Kira E et al (2022) Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Rep 40 111426 PMID: 36170823
David R et al (2021) Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux. Front Oncol 10 614288 PMID: 33598432
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.