Non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 377.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.65 mL||13.25 mL||26.49 mL|
|5 mM||0.53 mL||2.65 mL||5.3 mL|
|10 mM||0.26 mL||1.32 mL||2.65 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References are publications that support the biological activity of the product.
Liu & Coupar (1996) Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 117 787 PMID: 8851491
Fioretti et al (2017) Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 99 53 PMID: 28986330
Nonogaki & Kaji (2017) α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 18 35 PMID: 27939978
If you know of a relevant reference for Phentolamine Mesylate, please let us know.
View Related Products by Product Action
Keywords: Phentolamine Mesylate, Phentolamine Mesylate supplier, Phentolamine, non, selective, alpha, adrenergic, receptor, antagonists, antagonism, antihypertensive, adrenoceptor, Non-selective, Adrenergic, Alpha, Receptors, 6431, Tocris Bioscience
Citations for Phentolamine Mesylate
Citations are publications that use Tocris products.
Currently there are no citations for Phentolamine Mesylate. Do you know of a great paper that uses Phentolamine Mesylate from Tocris? Please let us know.
Reviews for Phentolamine Mesylate
There are currently no reviews for this product. Be the first to review Phentolamine Mesylate and earn rewards!
Have you used Phentolamine Mesylate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.