Phenserine

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Cat.No. 2967 - Phenserine | C20H23N3O2 | CAS No. 101246-66-6
Description: Cholinesterase inhibitor
Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate)
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.

Technical Data

M. Wt 337.42
Formula C20H23N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 101246-66-6
PubChem ID 192706
InChI Key PBHFNBQPZCRWQP-QUCCMNQESA-N
Smiles O=C(OC2=CC=C(N(C)[C@]4([H])[C@](C)3CCN4C)C3=C2)NC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.37 10
ethanol 8.44 25

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073 PMID: 15620572

Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide. J.Pharmacol.Exp.Ther. 318 855 PMID: 16690718

Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087 PMID: 17594192


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Keywords: Phenserine, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Cholinesterases, Tocris Bioscience

1 Citation for Phenserine

Citations are publications that use Tocris products. Selected citations for Phenserine include:

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Sci Rep 9 6 PMID: 25709566


Do you know of a great paper that uses Phenserine from Tocris? If so please let us know.

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Literature in this Area

Neurodegeneration

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Pathways for Phenserine

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