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Cat.No. 2967 - Phenserine | C20H23N3O2 | CAS No. 101246-66-6
Description: Cholinesterase inhibitor
Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate)
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity

Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.

Technical Data

M. Wt 337.42
Formula C20H23N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 101246-66-6
PubChem ID 192706
Smiles O=C(OC2=CC=C(N(C)[C@]4([H])[C@](C)3CCN4C)C3=C2)NC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.37 10
ethanol 8.44 25

Preparing Stock Solutions

The following data is based on the product molecular weight 337.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.85 mL 59.27 mL 118.55 mL
1.25 mM 2.37 mL 11.85 mL 23.71 mL
2.5 mM 1.19 mL 5.93 mL 11.85 mL
12.5 mM 0.24 mL 1.19 mL 2.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073 PMID: 15620572

Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide. J.Pharmacol.Exp.Ther. 318 855 PMID: 16690718

Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087 PMID: 17594192

If you know of a relevant reference for Phenserine, please let us know.

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Keywords: Phenserine, Phenserine supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Cholinesterases, Non-selective, Muscarinics, 2967, Tocris Bioscience

1 Citation for Phenserine

Citations are publications that use Tocris products. Selected citations for Phenserine include:

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Sci Rep 9 6 PMID: 25709566

Do you know of a great paper that uses Phenserine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.