PF 998425

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Cat.No. 3923 - PF 998425 | C14H14F3NO | CAS No. 1076225-27-8
Description: Non-steroidal androgen receptor antagonist
Chemical Name: 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective non-steroidal androgen receptor (AR) antagonist (IC50 values are 26 nM and 90 nM in AR binding assays and cellular assays respectively). Displays low affinity for progesterone receptor (IC50 > 10 μM). Active in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 269.26
Formula C14H14F3NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1076225-27-8
PubChem ID 25093231
InChI Key MENRRRXHFQYXDW-DGCLKSJQSA-N
Smiles O[C@H](CCCC2)[C@H]2[C@]1=CC(C(F)(F)F)=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.93 100
ethanol 26.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.57 mL 37.14 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2008) Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J.Med.Chem. 51 7010 PMID: 18921992


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