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PF 945863

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Cat.No. 4419 - PF 945863 | C44H65N5O10 | CAS No. 893556-85-9
Description: Macrolide antibiotic
Chemical Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Macrolide antibiotic. Active against multidrug resistant respiratory tract bacterial strains. Does not have the hepatotoxic side effects associated with telithromycin. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 824.01
Formula C44H65N5O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 893556-85-9
PubChem ID 90488939
InChI Key FATPJRUUPNLGGR-ACVHMLGSSA-N
Smiles O=C(N2C3CN([C@H](C)C4=C(C=CC=N5)C5=NC=C4)C3)O[C@](C2[C@H]1C)(C)[C@@H](CC)OC([C@H](C)C([C@H](C)[C@@H](O[C@@]6([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O6)[C@](C)(OC)C[C@@H](C)C1=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 82.4 100
ethanol 82.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 824.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.21 mL 6.07 mL 12.14 mL
5 mM 0.24 mL 1.21 mL 2.43 mL
10 mM 0.12 mL 0.61 mL 1.21 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Magee et al (2009) Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J.Med.Chem. 52 7446 PMID: 19775168

Zientek et al (2010) In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab.Dispos. 38 1322 PMID: 20444863

If you know of a relevant reference for PF 945863, please let us know.

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Keywords: PF 945863, PF 945863 supplier, PF945863, macrolide, antibiotics, multidrug, resistant, respiratory, tract, bacterial, Antibiotics, 4419, Tocris Bioscience

Citations for PF 945863

Citations are publications that use Tocris products.

Currently there are no citations for PF 945863. Do you know of a great paper that uses PF 945863 from Tocris? Please let us know.

Reviews for PF 945863

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Product used on mutated E.coli strains to see how the antibiotic strengths differ.
By Richard Whiteoak on 01/24/2019
Assay Type: In Vitro
Species: Other

PF 945863 was plated to measure antibiotic strength against mutated E.Coli strains.

review image

Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.

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