PF 945863

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Cat.No. 4419 - PF 945863 | C44H65N5O10 | CAS No. 893556-85-9
Description: Macrolide antibiotic
Chemical Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Macrolide antibiotic. Active against multidrug resistant respiratory tract bacterial strains. Does not have the hepatotoxic side effects associated with telithromycin. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 824.01
Formula C44H65N5O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 893556-85-9
PubChem ID 90488939
InChI Key FATPJRUUPNLGGR-ACVHMLGSSA-N
Smiles O=C(N2C3CN([C@H](C)C4=C(C=CC=N5)C5=NC=C4)C3)O[C@](C2[C@H]1C)(C)[C@@H](CC)OC([C@H](C)C([C@H](C)[C@@H](O[C@@]6([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O6)[C@](C)(OC)C[C@@H](C)C1=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 82.4 100
DMSO 82.4 100

Preparing Stock Solutions

The following data is based on the product molecular weight 824.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.21 mL 6.07 mL 12.14 mL
5 mM 0.24 mL 1.21 mL 2.43 mL
10 mM 0.12 mL 0.61 mL 1.21 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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References

References are publications that support the biological activity of the product.

Magee et al (2009) Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J.Med.Chem. 52 7446 PMID: 19775168

Zientek et al (2010) In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab.Dispos. 38 1322 PMID: 20444863


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Keywords: PF 945863, PF 945863 supplier, PF945863, macrolide, antibiotics, multidrug, resistant, respiratory, tract, bacterial, Antibiotics, 4419, Tocris Bioscience

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