PF 5081090

Pricing Availability Delivery Time Qty
Cat.No. 4362 - PF 5081090 | C18H21FN2O6S | CAS No. 1312473-63-4
Description: Potent LpxC inhibitor
Chemical Name: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC (IC50 = 1.1 nM in Pseudomonas aeruginosa); effective against a range of gram negative bacteria.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 412.43
Formula C18H21FN2O6S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1312473-63-4
PubChem ID 56964907
InChI Key DNVUWHWBCMGQLU-GOSISDBHSA-N
Smiles O=C1N(CC[C@]([S@@](C)(=O)=O)(C)C(NO)=O)C=CC(C2=CC=C(OC)C=C2F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 412.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.25 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Montgomery et al (2012) Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections. J.Med.Chem. 55 1662 PMID: 22257165


If you know of a relevant reference for PF 5081090, please let us know.

View Related Products by Target

Keywords: antibacterials gram negative LxpC lipid A bilayer synthesis inhibits inhibitors potent pfizer PF5081090 Antibiotics

Citations for PF 5081090

Citations are publications that use Tocris products.

Currently there are no citations for PF 5081090. Do you know of a great paper that uses PF 5081090 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for PF 5081090

Protocols

TODO: Add Protocols