PF 4778574

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Cat.No. 4900 - PF 4778574 | C19H22N2O3S2 | CAS No. 1219633-99-4
Description: Positive allosteric modulator of AMPA receptors
Chemical Name: N-[(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl]-2-propanesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Positive allosteric modulator of AMPA receptors (Ki = 85 nM). Prevents ketamine-induced working memory impairments. Brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 390.52
Formula C19H22N2O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1219633-99-4
PubChem ID 44462786
InChI Key FFAGHPLLBXWCSF-MSOLQXFVSA-N
Smiles O=S(N[C@H]1CCOC[C@@H]1[C@]2=CC=C(C3=CC=C(C#N)S3)C=C2)(C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.05 100
ethanol 19.53 50

Preparing Stock Solutions

The following data is based on the product molecular weight 390.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.8 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Roberts et al (2010) Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction. Behav.Brain Res. 212 41 PMID: 20347881

Doran et al (2012) An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations. Drug Metab.Dispos. 40 2162 PMID: 22899853

Shaffer et al (2013) Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574. J.Pharmacol.Exp.Ther. 347 212 PMID: 23899905


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Keywords: PF4778574 pam positive allosteric modulators potentiators ampa cognitive enhancers enhancement brain penetrant bbb AMPA Receptors

Citations for PF 4778574

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Pathways for PF 4778574

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