PF 06281355

Pricing Availability   Qty
Description: Selective myeloperoxidase (MPO) inhibitor
Chemical Name: 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
Purity: ≥98% (HPLC)

Biological Activity for PF 06281355

PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data for PF 06281355

M. Wt 321.35
Formula C14H15N3O4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1435467-38-1
PubChem ID 71568997
Smiles COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 06281355

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.43 20 with gentle warming

Preparing Stock Solutions for PF 06281355

The following data is based on the product molecular weight 321.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.56 mL 77.8 mL 155.59 mL
1 mM 3.11 mL 15.56 mL 31.12 mL
2 mM 1.56 mL 7.78 mL 15.56 mL
10 mM 0.31 mL 1.56 mL 3.11 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for PF 06281355

References are publications that support the biological activity of the product.

Zheng et al (2015) PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J.Pharmacol.Exp.Ther. 353 288 PMID: 25698787

Ruggeri et al (2015) Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J.Med.Chem. 58 8513 PMID: 26509551

If you know of a relevant reference for PF 06281355, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Oxygenase/Oxidase Inhibitors

Keywords: PF 06281355, PF 06281355 supplier, PF06281355, myeloperoxidase, inhibitors, inhibits, selective, orally, bioavailable, vasculitis, Other, Oxygenases/Oxidases, 6004, Tocris Bioscience

Citations for PF 06281355

Citations are publications that use Tocris products.

Currently there are no citations for PF 06281355. Do you know of a great paper that uses PF 06281355 from Tocris? Please let us know.

Reviews for PF 06281355

There are currently no reviews for this product. Be the first to review PF 06281355 and earn rewards!

Have you used PF 06281355?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review