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Submit ReviewPF 06281355
Description: Selective myeloperoxidase (MPO) inhibitor
Chemical Name: 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
Purity: ≥98% (HPLC)
Biological Activity for PF 06281355
PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc
Technical Data for PF 06281355
| M. Wt | 321.35 |
| Formula | C14H15N3O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1435467-38-1 |
| PubChem ID | 71568997 |
| InChI Key | LJBUZOGABRDGBR-UHFFFAOYSA-N |
| Smiles | COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 06281355
References for PF 06281355
References are publications that support the biological activity of the product.
Zheng et al (2015) PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J.Pharmacol.Exp.Ther. 353 288 PMID: 25698787
Ruggeri et al (2015) Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J.Med.Chem. 58 8513 PMID: 26509551
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Keywords: PF 06281355, PF 06281355 supplier, PF06281355, myeloperoxidase, inhibitors, inhibits, selective, orally, bioavailable, vasculitis, Other, Oxygenases/Oxidases, 6004, Tocris Bioscience
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