Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
Sold for research purposes under agreement from Pfizer Inc.
M. Wt | 396.36 |
Formula | C18H19F3N4O3 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1215197-37-7 |
PubChem ID | 46181428 |
InChI Key | GKMLFBRLRVQVJO-ZDUSSCGKSA-N |
Smiles | O=C(NC1=CC=C(C(O)=O)C=N1)[C@@H](N2C=NC(C(F)(F)F)=C2)CC3CCCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Pfefferkorn et al (2012) Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J.Med.Chem. 55 1318 PMID: 22196621
Keywords: PF 04991532, PF 04991532 supplier, PF04991532, glucokinase, activators, activates, potent, antidiabetic, Hexokinases, Enzyme, Substrates, /, Activators, 6345, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for PF 04991532.
There are currently no reviews for this product. Be the first to review PF 04991532 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image