PF 04991532

Discontinued Product

PF 04991532 (Cat. No. 6345) has been withdrawn from sale for commercial reasons.
Description: Potent hepatoselective glucokinase activator
Chemical Name: 6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for PF 04991532

PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 04991532

M. Wt 396.36
Formula C18H19F3N4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1215197-37-7
PubChem ID 46181428
Smiles O=C(NC1=CC=C(C(O)=O)C=N1)[C@@H](N2C=NC(C(F)(F)F)=C2)CC3CCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PF 04991532

References are publications that support the biological activity of the product.

Pfefferkorn et al (2012) Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J.Med.Chem. 55 1318 PMID: 22196621

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