Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPF 04991532
Discontinued Product
PF 04991532 (Cat. No. 6345) has been withdrawn from sale for commercial reasons.
Description: Potent hepatoselective glucokinase activator
Chemical Name: 6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for PF 04991532
PF 04991532 is a potent hepatoselective glucokinase activator (EC50 = 90 nM). Exhibits >50-fold liver to pancreas ratio of tissue distribution. Reduces fasting and postprandial glucose levels with no hypoglycemia in a rat diabetes model.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for PF 04991532
| M. Wt | 396.36 |
| Formula | C18H19F3N4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1215197-37-7 |
| PubChem ID | 46181428 |
| InChI Key | GKMLFBRLRVQVJO-ZDUSSCGKSA-N |
| Smiles | O=C(NC1=CC=C(C(O)=O)C=N1)[C@@H](N2C=NC(C(F)(F)F)=C2)CC3CCCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PF 04991532
References for PF 04991532
References are publications that support the biological activity of the product.
Pfefferkorn et al (2012) Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus. J.Med.Chem. 55 1318 PMID: 22196621
View Related Products by Target
View Related Products by Product Action
Keywords: PF 04991532, PF 04991532 supplier, PF04991532, glucokinase, activators, activates, potent, antidiabetic, Hexokinases, Enzyme, Substrates, /, Activators, 6345, Tocris Bioscience
Citations for PF 04991532
Citations are publications that use Tocris products.
Currently there are no citations for PF 04991532.
Reviews for PF 04991532
There are currently no reviews for this product. Be the first to review PF 04991532 and earn rewards!
Have you used PF 04991532?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product GuideNew
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.