PF 04937319

Pricing Availability Delivery Time Qty
Cat.No. 6049 - PF 04937319 | C22H20N6O4 | CAS No. 1245603-92-2
Description: Glucokinase partial activator
Chemical Name: N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Glucokinase partial activator (EC50 = 174 nM). Enhances glucose-stimulated insulin secretion in islet cell cultures and translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes in vitro. Reduces post-prandial plasma glucose levels in an oral glucose tolerance test in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

PF 04937319 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 432.43
Formula C22H20N6O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1245603-92-2
PubChem ID 46916694
InChI Key MASKQITXHVYVFL-UHFFFAOYSA-N
Smiles CC1=CC2=C(OC3=CN=C(C(N(C)C)=O)N=C3)C=C(C(NC4=CN=C(C)C=N4)=O)C=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 432.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Pfefferkorn et al (2011) Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 di Med.Chem.Commun., 2 828 PMID:

Pettersen et al (2014) The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicol. Pathol. 42 696 PMID: 24771080


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Keywords: PF 04937319, supplier, PF04937319, Glucokinase, partial, activators, activates, type, 2, diabetes, Hexokinases, Hexokinases, Tocris Bioscience

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