PF 04937319

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Cat.No. 6049 - PF 04937319 | C22H20N6O4 | CAS No. 1245603-92-2
Description: Glucokinase partial activator
Chemical Name: N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for PF 04937319

PF 04937319 is a glucokinase partial activator (EC50 = 174 nM). Enhances glucose-stimulated insulin secretion in islet cell cultures and translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes in vitro. Reduces post-prandial plasma glucose levels in an oral glucose tolerance test in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 04937319

M. Wt 432.43
Formula C22H20N6O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1245603-92-2
PubChem ID 46916694
Smiles CC1=CC2=C(OC3=CN=C(C(N(C)C)=O)N=C3)C=C(C(NC4=CN=C(C)C=N4)=O)C=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 04937319

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.24 100

Preparing Stock Solutions for PF 04937319

The following data is based on the product molecular weight 432.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for PF 04937319

References are publications that support the biological activity of the product.

Pfefferkorn et al (2011) Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 di Med.Chem.Commun., 2 828

Pettersen et al (2014) The relationship of glucokinase activator-induced hypoglycemia with arteriopathy, neuronal necrosis, and peripheral neuropathy in nonclinical studies. Toxicol. Pathol. 42 696 PMID: 24771080

If you know of a relevant reference for PF 04937319, please let us know.

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